Gallic Acid - Pharmacology
Research News and Information

Monday, November 23, 2009

Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2.

30 Jul 2009 Oxidative stress induced by reactive oxygen species (ROS) is strongly associated with the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease. We investigated the possible combined effects of gallic acid and ... Read more...

Gallic acid ester derivatives induce apoptosis and cell adhesion inhibition in melanoma cells: The relationship between free radical generation, glutathione depletion and cell death.

Jul 2009 Malignant melanoma is a lethal disease, and the incidence and mortality associated with it are increasing worldwide. It has a significant tendency to develop both metastasis and resistance to chemotherapy. The tumor cells show abnormal redox ... Read more...

Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice.

18 Jun 2009 PURPOSE: Gallic acid, a natural agent present in a wide-range of fruits and vegetables, has been of potential interest as an anti-cancer agent; herein, we evaluated its efficacy in androgen-independent DU145 and androgen-dependent-22Rv1 human ... Read more...

Latest indexed articles for 'Gallic Acid - Pharmacology'

These are the very latest articles for this heading:

• Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. 30 Jul 2009
• Gallic acid ester derivatives induce apoptosis and cell adhesion inhibition in melanoma cells: The relationship between free radical generation, glutathione depletion and cell death. Jul 2009
• Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. 18 Jun 2009
• Effect of gallic acid on the wear behavior of early carious enamel. 3 Jun 2009
• Gallotannin isolated from Euphorbia species, 1,2,6-tri-O-galloyl-beta-D-allose, decreases nitric oxide production through inhibition of nuclear factor-kappa>B and downstream inducible nitric oxide synthase expression in macrophages. 30 May 2009
• Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats. 13 May 2009
• Antibacterial activity of methyl gallate isolated from Galla Rhois or carvacrol combined with nalidixic acid against nalidixic acid resistant bacteria. 9 May 2009
• Occurrence and environmental stress responses of two plastid terminal oxidases in Haematococcus pluvialis (Chlorophyceae). 29 Apr 2009
• [In vitro activity of gallic acid against Candida albicans biofilms] 29 Apr 2009
• Gallic acid inhibits murine leukemia WEHI-3 cells in vivo and promotes macrophage phagocytosis. 29 Apr 2009
• A role for the Val291 residue within the transmembrane domain 2 in diltiazem- and TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester]-mediated 5-hydroxytryptamine type 3A receptor regulations. 29 Apr 2009
• Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. 19 Apr 2009
• Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic, radiographic and histomorphometric study in rats. 14 Apr 2009
• Relationships between free radical scavenging and antioxidant activity in foods. 6 Apr 2009
• Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells? 6 Apr 2009
• Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells. 3 Apr 2009
• Synthesis of (-)-epicatechin 3-(3-O-methylgallate) and (+)-catechin 3-(3-O-methylgallate), and their anti-inflammatory activity. 30 Mar 2009
• Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration. 30 Mar 2009
• Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. 30 Mar 2009
• Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H(2)O(2)/Cu(II), but potentiate DNA strand breaks by H(2)O(2)/Fe(II). 25 Mar 2009

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Technical information about 'Gallic Acid'

Definition: A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.

Chemical name: Benzoic acid, 3,4,5-trihydroxy-

Registry Number: 149-91-7

Descriptor UI: D005707

Alternative terms: Gallic Acid; Acid, Gallic; 3,4,5-Trihydroxybenzoic Acid;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.241.223.100.380.350; D02.241.511.390.350; D02.755.410.350;