gamma-Aminobutyric Acid - Analogs & derivatives
Research News and Information

Saturday, November 21, 2009

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

19 Oct 2009 Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological ... Read more...

Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells.

29 Sep 2009 BACKGROUND: Barrett's esophagus (BE) is the predominant risk factor for the development of esophageal adenocarcinoma. BE is characterized by intestinal metaplasia with goblet cells. Reflux of bile acids is known to induce intestinal metaplasia, but ... Read more...

Treatment of neuropathic pain: an overview of recent guidelines.

29 Sep 2009 A number of different treatments for neuropathic pain have been studied, but the literature is sizable, rapidly evolving, and lacks important information about practical aspects of patient management. Under the auspices of the International ... Read more...

Latest indexed articles for 'gamma-Aminobutyric Acid - Analogs & derivatives'

These are the very latest articles for this heading:

• T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. 19 Oct 2009
• Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. 29 Sep 2009
• Treatment of neuropathic pain: an overview of recent guidelines. 29 Sep 2009
• Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. 17 Aug 2009
• ST1859 reduces prion infectivity and increase survival in experimental scrapie. 13 Aug 2009
• Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales. 12 Aug 2009
• Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. 9 Aug 2009
• Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. 5 Aug 2009
• Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. 30 Jul 2009
• Pregabalin for fibromyalgia. 30 Jul 2009
• Fibromyalgia: poorly understood; treatments are disappointing. 30 Jul 2009
• Diagnosing and treating fibromyalgia. 30 Jul 2009
• An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy. 27 Jul 2009
• Pregabalin: a new approach to treatment of the dysautonomic crisis. 18 Jul 2009
• Pregabalin for acute and chronic pain in adults. 6 Jul 2009
• Oxaliplatin-induced hyperexcitability syndrome in a patient with pancreatic cancer. 4 Jul 2009
• [Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome] 29 Jun 2009
• Acute delirium in patients with multiple sclerosis treated with pregabalin. 29 Jun 2009
• The efficacy of pregabalin and benzodiazepines in generalized anxiety disorder presenting with high levels of insomnia. 29 Jun 2009
• Patient-reported outcomes in subjects with painful trigeminal neuralgia receiving pregabalin: evidence from medical practice in primary care settings. 29 Jun 2009

See a longer list of these articles.

Technical information about 'gamma-Aminobutyric Acid'

Definition: The most common inhibitory neurotransmitter in the central nervous system.

Chemical name: Butanoic acid, 4-amino-

Registry Number: 56-12-2

Descriptor UI: D005680

Alternative terms: gamma-Aminobutyric Acid; gamma Aminobutyric Acid; GABA; Aminalon; Aminalone; 4-Aminobutanoic Acid; 4 Aminobutanoic Acid; 4-Aminobutyric Acid; 4 Aminobutyric Acid; gamma-Aminobutyric Acid, Hydrochloride; Acid, Hydrochloride gamma-Aminobutyric; Hydrochloride gamma-Aminobutyric Acid; gamma Aminobutyric Acid, Hydrochloride; Gammalon; gamma-Aminobutyric Acid, Monosodium Salt; gamma Aminobutyric Acid, Monosodium Salt; gamma-Aminobutyric Acid, Zinc Salt (2:1); gamma-Aminobutyric Acid, Calcium Salt (2:1); gamma-Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Monolithium Salt; Lithium GABA; GABA, Lithium;

Related Mesh Headings: Receptors, GABA; GABA Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Pharmacological Action: GABA Agents;

Tree Number: D02.241.081.160.050.350; D12.125.190.350;

History Note: 2001(1975); use AMINOBUTYRIC ACIDS 1966-1974