gamma-Aminobutyric Acid - Pharmacology
Research News and Information

Monday, November 23, 2009

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

19 Oct 2009 Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological ... Read more...

Extrasynaptic GABAA receptors: form, pharmacology, and function.

12 Oct 2009 GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABA(A) ... Read more...

Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat.

8 Oct 2009 The expression and functionality of P2X/P2Y receptor subtypes in multipolar nonpyramidal neurons of mixed cortical cell cultures were investigated by means of immunocytochemistry and fura-2 microfluorimetry. The morphological studies revealed that ... Read more...

Latest indexed articles for 'gamma-Aminobutyric Acid - Pharmacology'

These are the very latest articles for this heading:

• T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. 19 Oct 2009
• Extrasynaptic GABAA receptors: form, pharmacology, and function. 12 Oct 2009
• Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat. 8 Oct 2009
• Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 6 Oct 2009
• Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. 29 Sep 2009
• GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. 28 Sep 2009
• Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. 28 Sep 2009
• Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction. 21 Sep 2009
• Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons. 14 Sep 2009
• Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. 14 Sep 2009
• Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. 17 Aug 2009
• Proline antagonizes GABA-induced quenching of quorum-sensing in Agrobacterium tumefaciens. 11 Aug 2009
• Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. 9 Aug 2009
• Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. 5 Aug 2009
• Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. 30 Jul 2009
• gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype. 30 Jul 2009
• Intensity of GABA-evoked responses is modified by nitric oxide-active compounds in the subthalamic nucleus of the rat: a microiontophoretic study. 30 Jul 2009
• Ca(2+) signaling evoked by activation of Na(+) channels and Na(+)/Ca(2+) exchangers is required for GABA-induced NG2 cell migration. 11 Jul 2009
• Synthesis, radiosynthesis and biological evaluation of 1,4-dihydroquinoline derivatives as new carriers for specific brain delivery. 8 Jul 2009
• [Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus] 29 Jun 2009

See a longer list of these articles.

Technical information about 'gamma-Aminobutyric Acid'

Definition: The most common inhibitory neurotransmitter in the central nervous system.

Chemical name: Butanoic acid, 4-amino-

Registry Number: 56-12-2

Descriptor UI: D005680

Alternative terms: gamma-Aminobutyric Acid; gamma Aminobutyric Acid; GABA; Aminalon; Aminalone; 4-Aminobutanoic Acid; 4 Aminobutanoic Acid; 4-Aminobutyric Acid; 4 Aminobutyric Acid; gamma-Aminobutyric Acid, Hydrochloride; Acid, Hydrochloride gamma-Aminobutyric; Hydrochloride gamma-Aminobutyric Acid; gamma Aminobutyric Acid, Hydrochloride; Gammalon; gamma-Aminobutyric Acid, Monosodium Salt; gamma Aminobutyric Acid, Monosodium Salt; gamma-Aminobutyric Acid, Zinc Salt (2:1); gamma-Aminobutyric Acid, Calcium Salt (2:1); gamma-Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Monolithium Salt; Lithium GABA; GABA, Lithium;

Related Mesh Headings: Receptors, GABA; GABA Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Pharmacological Action: GABA Agents;

Tree Number: D02.241.081.160.050.350; D12.125.190.350;

History Note: 2001(1975); use AMINOBUTYRIC ACIDS 1966-1974