GAP-43 Protein - Chemistry
Research News and Information

Sunday, November 22, 2009

Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system.

30 Jan 2009 Songbirds are appreciated for the insights they provide into regulated neural plasticity. Here, we describe the comparative analysis and brain expression of two gene sequences encoding probable regulators of synaptic plasticity in songbirds: ... Read more...

3.6 kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons.

22 May 2008 Unlike mammals, fish have the capacity for functional adult CNS regeneration, which is due, in part, to their ability to express axon growth-related genes in response to nerve injury. One such axon growth-associated gene is gap43, which is expressed ... Read more...

Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.

30 Dec 2007 HuD is a neuronal RNA-binding protein associated with the stabilization of mRNAs for GAP-43 and other neuronal proteins that are important for nervous system development and learning and memory mechanisms. To better understand the function of this ... Read more...

Latest indexed articles for 'GAP-43 Protein - Chemistry'

These are the very latest articles for this heading:

• Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system. 30 Jan 2009
• 3.6 kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons. 22 May 2008
• Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. 30 Dec 2007
• Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayers. 5 Sep 2007
• Biphasic Ca2+-dependent switching in a calmodulin-IQ domain complex. 4 Jun 2006
• Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. 30 Jul 2005
• Identification of myristoylated alanine-rich C kinase substrate (MARCKS) in astrocytes. 30 Dec 2004
• Growth-associated protein of 43 kDa (GAP-43) is cleaved nonprocessively by the 20S proteasome. 30 May 2004
• Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. 22 Jun 2002
• Site-specific calcium-dependent proteolysis of neuronal protein GAP-43. 30 Mar 2001
• Enhancement by Mg2+ of domain specificity in Ca2+-dependent interactions of calmodulin with target sequences. 29 Nov 2000
• Enhanced level of site-specific proteolysis of GAP-43 protein during early stages of brain development. 29 Sep 2000
• Small proteins that modulate calmodulin-dependent signal transduction: effects of PEP-19, neuromodulin, and neurogranin on enzyme activation and cellular homeostasis. 30 Jul 2000
• Bacteriophage lambda display of complex cDNA libraries: a new approach to functional genomics. 16 Feb 2000
• Microscale purification of proteins exhibiting anomalous electrophoretic migration: application to the analysis of GAP-43 phosphorylation. 13 Oct 1999
• 1,2-dioctanoyl-s,n-glycerol-induced activation of protein kinase C results in striking, but reversible growth cone shape changes and an accumulation of f-actin and serine 41-phosphorylated GAP-43 in the axonal process. 29 Sep 1999
• Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus. 10 Aug 1999
• Hypoxia/ischemia induces dephosphorylation of rat brain neuromodulin/GAP-43 in vivo. 27 Feb 1999
• Influence of lipid on the structure and phosphorylation of protein kinase C alpha substrate peptides. 13 Mar 1998
• Structure and position of the N-terminal membrane-binding domain of pp60src at the membrane interface. 8 Mar 1998

See a longer list of these articles.

Technical information about 'GAP-43 Protein'

Definition: A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.

Registry Number: 0

Descriptor UI: D019922

Alternative terms: GAP-43 Protein; GAP 43 Protein; B-50 Protein; B 50 Protein; GAP-43; Phosphoprotein F1; Growth-Associated Protein 43; Growth Associated Protein 43; Nerve Growth Cone Membrane Protein GAP-43; Nerve Growth Cone Membrane Protein GAP 43; Neuromodulin; Phosphoprotein B-50; Phosphoprotein B 50; Phosphoprotein pp46; GAP43 Protein;

Allowable Qualifiers: therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution;

Tree Number: D12.776.395.550.400; D12.776.543.550.400; D12.776.641.400;

History Note: 98; use GAP-43 PROTEIN (NM) 1986-97