GAP-43 Protein - Genetics
Research News and Information

Sunday, November 22, 2009

Changes in markers of neuronal and glial plasticity after cortical injury induced by food restriction.

2 Sep 2009 The regenerative capacity of the adult central nervous system is limited. We investigated whether short-term food restriction (FR; 50% of the daily food intake lasting 3 months) modulates processes of brain plasticity after cortical injury. ... Read more...

Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?

30 Aug 2009 Although deregulated Hedgehog signalling and elevated Gli transcription factor expression are known to promote the development of basal cell carcinoma (BCC), little is known about molecular mechanisms driving the development of specific growth ... Read more...

Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway.

13 Jul 2009 GAP-43 (growth-associated protein-43) is a dually palmitoylated protein, at cysteine residues at positions 3 and 4, that mostly localizes in plasma membrane both in neural and non-neural cells. In the present study, we have examined membrane ... Read more...

Latest indexed articles for 'GAP-43 Protein - Genetics'

These are the very latest articles for this heading:

• Changes in markers of neuronal and glial plasticity after cortical injury induced by food restriction. 2 Sep 2009
• Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation? 30 Aug 2009
• Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway. 13 Jul 2009
• Expression of the neural specific protein, GAP-43, dramatically lengthens the cell cycle in fibroblasts. 5 Jul 2009
• Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis. 31 May 2009
• Dynamic expression of neurogenic markers in the developing chick olfactory epithelium. 30 May 2009
• Regulation of GAP-43 at serine 41 acts as a switch to modulate both intrinsic and extrinsic behaviors of growing neurons, via altered membrane distribution. 24 Feb 2009
• Pathologic changes in chronic intraorbital optic nerve damage in rabbits. 18 Feb 2009
• Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. 9 Feb 2009
• Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system. 30 Jan 2009
• GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. 7 Jan 2009
• Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: behavioral and molecular evidence. 27 Dec 2008
• A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. 3 Dec 2008
• Odorant receptor (OR) gene choice is biased and non-clonal in two olfactory placode cell lines, and OR RNA is nuclear prior to differentiation of these lines. 10 Nov 2008
• Characterization of a nervous system-specific promoter for growth-associated protein 43 gene in Medaka (Oryzias latipes). 5 Oct 2008
• p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. 9 Sep 2008
• The effects of FGF-2 gene therapy combined with voluntary exercise on axonal regeneration across peripheral nerve gaps. Aug 2008
• Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 12 Jul 2008
• BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Jul 2008
• Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation. 29 Jun 2008

See a longer list of these articles.

Technical information about 'GAP-43 Protein'

Definition: A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.

Registry Number: 0

Descriptor UI: D019922

Alternative terms: GAP-43 Protein; GAP 43 Protein; B-50 Protein; B 50 Protein; GAP-43; Phosphoprotein F1; Growth-Associated Protein 43; Growth Associated Protein 43; Nerve Growth Cone Membrane Protein GAP-43; Nerve Growth Cone Membrane Protein GAP 43; Neuromodulin; Phosphoprotein B-50; Phosphoprotein B 50; Phosphoprotein pp46; GAP43 Protein;

Allowable Qualifiers: therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution;

Tree Number: D12.776.395.550.400; D12.776.543.550.400; D12.776.641.400;

History Note: 98; use GAP-43 PROTEIN (NM) 1986-97