GAP-43 Protein - Metabolism
Research News and Information

Sunday, November 22, 2009

Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury.

27 Oct 2009 Despite advances in promoting axonal regeneration after acute spinal cord injury (SCI), elicitation of bridging axon regeneration after chronic SCI remains a formidable challenge. We report that combinatorial therapies administered 6 weeks, and as ... Read more...

Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract.

18 Oct 2009 To investigate the neural basis for functional recovery of the cerebral cortex following spinal cord injury, we measured the expression of growth-associated protein 43 (GAP-43), which is involved in the process of synaptic sprouting. We determined ... Read more...

Changes in markers of neuronal and glial plasticity after cortical injury induced by food restriction.

2 Sep 2009 The regenerative capacity of the adult central nervous system is limited. We investigated whether short-term food restriction (FR; 50% of the daily food intake lasting 3 months) modulates processes of brain plasticity after cortical injury. ... Read more...

Latest indexed articles for 'GAP-43 Protein - Metabolism'

These are the very latest articles for this heading:

• Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. 27 Oct 2009
• Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract. 18 Oct 2009
• Changes in markers of neuronal and glial plasticity after cortical injury induced by food restriction. 2 Sep 2009
• Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway. 13 Jul 2009
• Expression of the neural specific protein, GAP-43, dramatically lengthens the cell cycle in fibroblasts. 5 Jul 2009
• Insulin with chondroitinase ABC treats the rat model of acute spinal cord injury. 29 Jun 2009
• Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+) implanted-Parkinson's model. 29 Jun 2009
• Dynamic expression of neurogenic markers in the developing chick olfactory epithelium. 30 May 2009
• Nuclear factor-kappaB activation in axons and Schwann cells in experimental sciatic nerve injury and its role in modulating axon regeneration: studies with etanercept. 30 May 2009
• Effect of intranasal administration of basic fibroblast growth factor on olfactory epithelium. 25 May 2009
• Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells. 20 May 2009
• NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation. 12 May 2009
• Central auditory plasticity after carboplatin-induced unilateral inner ear damage in the chinchilla: up-regulation of GAP-43 in the ventral cochlear nucleus. 8 May 2009
• Melatonin attenuates methamphetamine-induced reduction of tyrosine hydroxylase, synaptophysin and growth-associated protein-43 levels in the neonatal rat brain. 2 May 2009
• Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion. 29 Apr 2009
• AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors. 29 Apr 2009
• Exposure to polybrominated diphenyl ethers 203 and 206 during the neonatal brain growth spurt affects proteins important for normal neurodevelopment in mice. 18 Apr 2009
• Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. 29 Mar 2009
• Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. 26 Mar 2009
• Recombinant ciliary neurotrophic factor promotes nerve regeneration and induces gene expression in silicon tube-bridged transected sciatic nerves in adult rats. 14 Mar 2009

See a longer list of these articles.

Technical information about 'GAP-43 Protein'

Definition: A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.

Registry Number: 0

Descriptor UI: D019922

Alternative terms: GAP-43 Protein; GAP 43 Protein; B-50 Protein; B 50 Protein; GAP-43; Phosphoprotein F1; Growth-Associated Protein 43; Growth Associated Protein 43; Nerve Growth Cone Membrane Protein GAP-43; Nerve Growth Cone Membrane Protein GAP 43; Neuromodulin; Phosphoprotein B-50; Phosphoprotein B 50; Phosphoprotein pp46; GAP43 Protein;

Allowable Qualifiers: therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution;

Tree Number: D12.776.395.550.400; D12.776.543.550.400; D12.776.641.400;

History Note: 98; use GAP-43 PROTEIN (NM) 1986-97