GATA3 Transcription Factor - Genetics
Research News and Information

Sunday, November 22, 2009

PU.1 regulates TCR expression by modulating GATA-3 activity.

13 Oct 2009 The Ets transcription factor PU.1 is a master regulator for the development of multiple lineages during hematopoiesis. The expression pattern of PU.1 is dynamically regulated during early T lineage development in the thymus. We previously revealed ... Read more...

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

10 Oct 2009 Type I diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells, and effective treatment of the disease might require rescuing beta cell function in a context of reinstalled immune tolerance. Sertoli cells (SCs) are found in ... Read more...

Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes.

31 Aug 2009 The zinc-finger transcription factors Gata3 and ThPOK have both been implicated in positive selection of double positive (DP) thymocytes towards the CD4 lineage. As in the absence of Gata3, expression of ThPOK is lacking, Gata3 may directly regulate ... Read more...

Latest indexed articles for 'GATA3 Transcription Factor - Genetics'

These are the very latest articles for this heading:

• PU.1 regulates TCR expression by modulating GATA-3 activity. 13 Oct 2009
• Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
• Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes. 31 Aug 2009
• Transcription factor GATA-3 is essential for lens development. 30 Aug 2009
• A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. 30 Aug 2009
• T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. 31 Jul 2009
• HDR (Hypoparathyroidism, Deafness, Renal dysplasia) syndrome associated to GATA3 gene duplication. 29 Jun 2009
• Glycoprotein isolated from Dioscorea batatas Decne modulates expressions of IL-4 and IL-10 in primary-cultured mouse lymphocytes. 29 Jun 2009
• Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression. 27 Jun 2009
• Stemucronatoside L, a pregnane glycoside from the roots of Stephanotis mucronata, inhibits Th1/Th2 immune responses in vitro. 30 May 2009
• GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. 30 May 2009
• GATA-3 is upregulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome. 30 May 2009
• Expression of GATA3, T-bet, IL-4, and IFN-gamma mRNA in the effusion of OME patients. 27 May 2009
• In mice lacking V2a interneurons, gait depends on speed of locomotion. 25 May 2009
• Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses. 9 May 2009
• CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. 3 May 2009
• Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer. 28 Apr 2009
• Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. 26 Apr 2009
• Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. 3 Apr 2009
• Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children. 30 Mar 2009

See a longer list of these articles.

Technical information about 'GATA3 Transcription Factor'

Definition: A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.

Registry Number: 0

Descriptor UI: D050990

Alternative terms: GATA3 Transcription Factor; Transcription Factor, GATA3; NF-E1C Protein; NF E1C Protein; GATA-3 Factors; GATA 3 Factors; Transcription Factor GATA3; GATA3, Transcription Factor; Nuclear Factor-Erythroid 1C; Nuclear Factor Erythroid 1C;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.235.687; D12.776.260.257.300; D12.776.930.316.687; D12.776.930.321.300;

History Note: 2006(1991)