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Gene Amplification
Research News and Information
Definition of 'Gene Amplification'A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. |
Monday, November 23, 2009
30 Oct 2009 
TERC gene amplification was investigated as a possible diagnostic marker for use in routine cytological screening to improve the accuracy of conventional screening procedures in detection of cervical preneoplastic lesions. Cervical smears were ... Read more...
30 Oct 2009 Genetic alteration in oral premalignant lesions (OPLs), the precursors of oral squamous cell carcinomas (OSCCs), may represent key changes in disease initiation and development. We ask if DNA amplification occurs at this early stage of cancer ... Read more...
Amplification and expression of EGFR and ERBB2 in Wilms tumor.
13 Oct 2009 Wilms tumor is one of the most common solid tumors in children. We evaluated expression and amplification of a number of genes and their prognostic significance in 45 patients with Wilms tumor, using tissue microarray technology. The expression of ... Read more...
Latest indexed articles for 'Gene Amplification'
These are the very latest articles for this heading:
- FGFR3 amplification in the absence of IGH@-FGFR3 fusion t(4;14) in myeloma.
30 Oct 2009 - Screening of TERC gene amplification as an additional genetic diagnostic test in detection of cervical preneoplastic lesions. 30 Oct 2009
- Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. 30 Oct 2009
- Amplification and expression of EGFR and ERBB2 in Wilms tumor. 13 Oct 2009
- Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. 13 Oct 2009
- Chk2 protects against radiation-induced genomic instability. 29 Sep 2009
- Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics. 29 Sep 2009
- Esterase-based resistance in the tobacco-adapted form of the green peach aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae) in the eastern United States. 29 Sep 2009
- Centrosome amplification induced by the antiretroviral nucleoside reverse transcriptase inhibitors lamivudine, stavudine, and didanosine. 29 Sep 2009
- HER2/neu (c-erbB-2) gene amplification and protein expression are rare in uterine cervical neoplasia: a tissue microarray study of 814 archival specimens. 29 Sep 2009
- Emerging technologies for assessing HER2 amplification. 29 Sep 2009
- In situ evidence of KRAS amplification and association with increased p21 levels in non-small cell lung carcinoma. 29 Sep 2009
- Amplification of the ABCB1 region accompanied by a short sequence of 200bp from chromosome 2 in lung cancer cells. 29 Sep 2009
- Direct selection for ribozyme cleavage activity in cells. 21 Sep 2009
- Duplications of the functional CYP21A2 gene are primarily restricted to Q318X alleles: evidence for a founder effect. 20 Sep 2009
- The effect of replication initiation on gene amplification in the rDNA and its relationship to aging. 9 Sep 2009
- Development of quantitative real-time polymerase chain reaction for detection of and discrimination between Erysipelothrix rhusiopathiae and other Erysipelothrix species. 30 Aug 2009
- A first case of ehrlichiosis in a horse in Poland. 30 Aug 2009
- Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis. 30 Aug 2009
- Be precise! The need to consider the mechanisms for CEP17 copy number changes in breast cancer. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Gene Amplification'
Definition: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Descriptor UI: D005784
Alternative terms: Gene Amplification; Amplification, Gene;
Related Mesh Headings: Gene Dosage;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;
Tree Number: G05.355.315.250; G05.355.600.315; G05.365.590.310;
History Note: 80
Technical Notes: for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics