Gene Expression Regulation - Drug effects
Research News and Information

Saturday, November 21, 2009

PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc.

29 Nov 2009 The goal of the investigation was to test the hypothesis that the phosphoinositide-3 kinase (PI3K)/AKT signaling pathway regulates the expression of the major extracellular matrix component of the intervertebral disc, aggrecan, in nucleus pulposus ... Read more...

Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus.

30 Oct 2009 Neurofibromatosis 1 (NF1) is a common single-gene disorder that causes learning impairments in patients. Neurofibromin encoded by the NF1 causal gene regulates Ras/MAPK and cAMP signaling pathways. These signaling pathways play critical roles in ... Read more...

Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine dietary selenium requirements in rats.

30 Oct 2009 Transcript (mRNA) levels are increasingly being used in medicine as molecular biomarkers for disease and disease risk, including use of whole blood as a target tissue for analysis. Development of blood molecular biomarkers for nutritional status, ... Read more...

Latest indexed articles for 'Gene Expression Regulation - Drug effects'

These are the very latest articles for this heading:

• PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. 29 Nov 2009
• Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus. 30 Oct 2009
• Spermidine surprise for a long life. 30 Oct 2009
• Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine dietary selenium requirements in rats. 30 Oct 2009
• RAGE expression and NF-kappaB activation attenuated by extracellular domain of RAGE in human salivary gland cell line. 30 Oct 2009
• Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11. 30 Oct 2009
• Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat. 19 Oct 2009
• Protein phosphatase 1 regulates the histone code for long-term memory. 12 Oct 2009
• Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli. 12 Oct 2009
• Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. 12 Oct 2009
• Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts. 10 Oct 2009
• Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. 3 Oct 2009
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. 3 Oct 2009
• Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. 29 Sep 2009
• Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. 29 Sep 2009
• Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. 29 Sep 2009
• Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. 29 Sep 2009
• Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. 29 Sep 2009
• Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. 29 Sep 2009
• Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Gene Expression Regulation'

Definition: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Descriptor UI: D005786

Alternative terms: Gene Expression Regulation; Gene Action Regulation; Regulation, Gene Action; Regulation, Gene Expression; Expression Regulation, Gene; Regulation of Gene Expression;

Related Mesh Headings: Cell Differentiation; Chromosomal Proteins, Non-Histone; Transcription Factors; Trans-Activators;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G05.355.315;

History Note: 81

Technical Notes: general or unspecified; prefer specifics; DF: GENE EXPRESSION REG