Gene Rearrangement
Research News and Information

Sunday, November 22, 2009

Differential utilization of T cell receptor TCRalpha/TCRdelta locus variable region gene segments is mediated by accessibility.

26 Sep 2009 T cell receptor (TCR) variable region exons are assembled from germline V, (D), and J gene segments, each of which is flanked by recombination signal (RS) sequences that are composed of a conserved heptamer, a spacer of 12 or 23 bp, and a ... Read more...

The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma.

30 Aug 2009 Alveolar rhabdomyosarcoma (ARMS) is an aggressive neoplasm with unique t(2;13)(q35;q14) or t(1;13)(p36;q14) chromosomal translocations, resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, in approximately 80% of cases. These translocations and ... Read more...

Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.

30 Aug 2009 The oncogene v-akt was isolated from a retrovirus that induced naturally occurring thymic lymphomas in AKR mice. We hypothesized that constitutive activation of Akt2 could serve as a first hit for the clonal expansion of malignant T-cells by ... Read more...

Latest indexed articles for 'Gene Rearrangement'

These are the very latest articles for this heading:

• Array-CGH detection of a de novo 0.7-Mb deletion in 19p13.13 including CACNA1A associated with mental retardation and epilepsy with infantile spasms. 30 Oct 2009
• CASP8AP2 is a novel partner gene of MLL rearrangement with t(6;11)(q15;q23) in acute myeloid leukemia. 30 Oct 2009
• Low frequency of EWSR1 rearrangements in neoplasms classified as high-risk Wilms tumors. 29 Sep 2009
• Differential utilization of T cell receptor TCRalpha/TCRdelta locus variable region gene segments is mediated by accessibility. 26 Sep 2009
• The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma. 30 Aug 2009
• Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice. 30 Aug 2009
• Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding. 30 Aug 2009
• Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement. 23 Aug 2009
• MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. 22 Aug 2009
• RecQ helicases: multifunctional genome caretakers. 4 Aug 2009
• Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol. 3 Aug 2009
• Retrotransposon overdose and genome integrity. 2 Aug 2009
• Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. Aug 2009
• [Fetal cell carcinogenesis hypothesis and the prospect of future laboratory tests] 30 Jul 2009
• Array-CGH analysis indicates a high prevalence of genomic rearrangements in holoprosencephaly: an updated map of candidate loci. 30 Jul 2009
• Molecular diagnosis of hematopoietic and lymphoid neoplasms. 30 Jul 2009
• Acute lymphoblastic leukemia. 30 Jul 2009
• Molecular characterization of post-transplant lymphoproliferative disorders of donor origin occurring in liver transplant recipients. 30 Jul 2009
• Primary intraocular lymphoma. 30 Jul 2009
• Chronic myelogenous leukemia with the e6a2 BCR-ABL and lacking imatinib response: presentation of two cases. 27 Jul 2009

See a longer list of these articles.

Technical information about 'Gene Rearrangement'

Definition: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

Descriptor UI: D015321

Alternative terms: Gene Rearrangement; Gene Rearrangements; Rearrangement, Gene; Rearrangements, Gene; DNA Rearrangement; DNA Rearrangements; Rearrangement, DNA; Rearrangements, DNA;

Related Mesh Headings: Antibody Diversity; Genes, Immunoglobulin; Immunoglobulin Variable Region; Translocation, Genetic; VDJ Recombinases;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G05.355.330;

History Note: 89

Technical Notes: DF: GENE REARR