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Gene Regulatory Networks
Research News and Information
Definition of 'Gene Regulatory Networks'Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations. Common names: Gene Regulatory Networks; Gene Regulatory Network; Network, Gene Regulatory; Networks, Gene Regulatory; Regulatory Network, Gene; Regulatory Networks, Gene; Transcriptional Networks; Network, Transcriptional; Networks, Transcriptional; Transcriptional Network; Gene Networks; Gene Network |
Saturday, November 21, 2009
6 Oct 2009 
The transcription factor PU.1, encoded by the Sfpi1 gene, functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage fate. We demonstrated that Gfi1 reciprocally promoted B cell fate ... Read more...
MicroRNA expression, survival, and response to interferon in liver cancer.
6 Oct 2009 BACKGROUND: Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease. METHODS: We analyzed three ... Read more...
Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform.
29 Sep 2009 PURPOSE: The discovery of effective biomarkers is a fundamental goal of molecular medicine. Developing a systems-biology understanding of radiosensitivity can enhance our ability of identifying radiation-specific biomarkers. METHODS AND MATERIALS: ... Read more...
Latest indexed articles for 'Gene Regulatory Networks'
These are the very latest articles for this heading:
- Genetics. Life after GWA studies.
7 Oct 2009 - A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. 6 Oct 2009
- MicroRNA expression, survival, and response to interferon in liver cancer. 6 Oct 2009
- Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. 29 Sep 2009
- FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. 29 Sep 2009
- Characterization of WRKY co-regulatory networks in rice and Arabidopsis. 20 Sep 2009
- H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. 15 Sep 2009
- A gene network for long-day flowering activates RFT1 encoding a mobile flowering signal in rice. 15 Sep 2009
- miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. 9 Sep 2009
- Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. 8 Sep 2009
- Repressor lattice: feedback, commensurability, and dynamical frustration. 8 Sep 2009
- Molecular networks as sensors and drivers of common human diseases. 8 Sep 2009
- Systems biology of stem cell fate and cellular reprogramming. 7 Sep 2009
- Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Sep 2009
- Genetic susceptibility loci in rheumatoid arthritis establish transcriptional regulatory networks with other genes. 30 Aug 2009
- Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective. 30 Aug 2009
- Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. 29 Aug 2009
- Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. 24 Aug 2009
- Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor. 23 Aug 2009
- Identification of network topological units coordinating the global expression response to glucose in Bacillus subtilis and its comparison to Escherichia coli. 22 Aug 2009
See a longer list of these articles.
Technical information about 'Gene Regulatory Networks'
Definition: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Descriptor UI: D053263
Alternative terms: Gene Regulatory Networks; Gene Regulatory Network; Network, Gene Regulatory; Networks, Gene Regulatory; Regulatory Network, Gene; Regulatory Networks, Gene; Transcriptional Networks; Network, Transcriptional; Networks, Transcriptional; Transcriptional Network; Gene Networks; Gene Network; Network, Gene; Networks, Gene; Gene Modules; Module, Gene; Modules, Gene; Gene Module; Gene Circuits; Circuit, Gene; Circuits, Gene; Gene Circuit;
Related Mesh Headings: Gene Expression Regulation;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;
Tree Number: G05.360.080.689.360;
History Note: 2007