Genes, erbB-1
Research News and Information

Saturday, November 21, 2009

Amplification and expression of EGFR and ERBB2 in Wilms tumor.

13 Oct 2009 Wilms tumor is one of the most common solid tumors in children. We evaluated expression and amplification of a number of genes and their prognostic significance in 45 patients with Wilms tumor, using tissue microarray technology. The expression of ... Read more...

DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin.

29 Sep 2009 One of the hallmarks of carcinomas is epithelial disorganization, linked to overexpression of matrix metalloproteases (MMP) like MMP-9, loss of intercellular E-cadherin and activation of epidermal growth receptor (EGFR/erbB1). Since the p53 tumor ... Read more...

Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.

30 Aug 2009 PURPOSE: Concurrent temozolomide (TMZ) and radiation therapy (RT) followed by adjuvant TMZ is standard treatment for patients with glioblastoma multiforme (GBM), although the relative contribution of concurrent versus adjuvant TMZ is unknown. In ... Read more...

Latest indexed articles for 'Genes, erbB-1'

These are the very latest articles for this heading:

• Amplification and expression of EGFR and ERBB2 in Wilms tumor. 13 Oct 2009
• DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin. 29 Sep 2009
• Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. 30 Aug 2009
• Mucinous gastric carcinomas: clinicopathologic and molecular analyses. 30 Jul 2009
• Lack of association between common polymorphisms of epidermal growth factor receptors and nonsyndromic cleft lip with or without cleft palate. 29 Jun 2009
• [Small-molecule tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR)] 29 Jun 2009
• Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations. 14 Jun 2009
• Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma. 9 Jun 2009
• Role of the C-terminal linear region of EGF-like growth factors in ErbB specificity. 30 May 2009
• Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer. 30 May 2009
• Expression of ABC transporters, p53, Bax, Bcl-2 in an archival sample of non-small cell lung cancer bearing a deletion in the EGFR gene. 29 Apr 2009
• Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile. 29 Apr 2009
• Role of immunohistochemistry in the diagnosis of lung cancer. 30 Mar 2009
• Retinoid X receptor overexpression desensitizes laryngeal epithelium to carcinogenic effects associated with epidermal growth factor receptor upregulation. 30 Mar 2009
• Exclusion of EGFR, HRAS, DSP, JUP, CTNNB1, PLEC1, and EPPK1 as functional candidate genes in 7 families with syndromic diarrhoea. 30 Mar 2009
• Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. 30 Mar 2009
• Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. 30 Mar 2009
• EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma. 26 Mar 2009
• Tiling path genomic profiling of grade 3 invasive ductal breast cancers. 22 Mar 2009
• Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer. 8 Mar 2009

See a longer list of these articles.

Technical information about 'Genes, erbB-1'

Definition: The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.

Descriptor UI: D018773

Alternative terms: Genes, erbB-1; Genes, erbB1; Gene, erbB1; erbB1 Gene; erbB1 Genes; erbB-1 Genes; erbB 1 Genes; erbB-1 Gene; v-erbB Genes; v erbB Genes; v-erbB Gene; v-erbB Oncogenes; v erbB Oncogenes; v-erbB Oncogene; c-erbB-1 Genes; c erbB 1 Genes; c-erbB-1 Gene; EGFR Genes; Epidermal Growth Factor Receptor Genes; c-erbB-1 Proto-Oncogenes; c erbB 1 Proto Oncogenes; c-erbB-1 Proto-Oncogene; Genes, EGFR; EGFR Gene;

Related Mesh Headings: Receptor, Epidermal Growth Factor; Oncogene Proteins v-erbB;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G05.360.340.024.340.375.500.791.295.300;

History Note: 95

Technical Notes: spell in titles & translations as erbB-1; GENES, ERBB-2 is also available