Genetic Predisposition to Disease
Research News and Information

Saturday, November 21, 2009

Genetic complexity of absence seizures in substrains of C3H mice.

15 Dec 2009 Absence epilepsy is a common form of idiopathic generalized epilepsy whose etiology is poorly understood because of genetic and phenotypic heterogeneity. The inbred mouse strain C3H/He exhibits spontaneous absence seizures characterized by spike and ... Read more...

Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk.

13 Dec 2009 BACKGROUND: Our original studies reported an association between the iron-metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effect on cell proliferation, iron is involved ... Read more...

Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?

5 Dec 2009 Schizophrenia is a complex neuropsychiatric disorder whose etiology involves a mixture of genetic and environmental factors. By virtue of this complexity, schizophrenia is a field of research in which a number of key technologies converge: in ... Read more...

Latest indexed articles for 'Genetic Predisposition to Disease'

These are the very latest articles for this heading:

• Genetic complexity of absence seizures in substrains of C3H mice. 15 Dec 2009
• Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk. 13 Dec 2009
• Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes? 5 Dec 2009
• Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor. 29 Nov 2009
• The heritability and genetics of frontotemporal lobar degeneration. Nov 2009
• Two distinct subtypes of right temporal variant frontotemporal dementia. Nov 2009
• Common CCR 5 polymorphism in stroke: the CCR 5 delta32 polymorphism differentiates cardioembolism from other aetiologies of ischaemic cerebrovascular diseases. 30 Oct 2009
• Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. 30 Oct 2009
• Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population. 30 Oct 2009
• Sarcoidosis: epidemiology, etiology, pathogenesis, and genetics. 30 Oct 2009
• Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. 30 Oct 2009
• Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms. 30 Oct 2009
• Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. 30 Oct 2009
• Regarding "Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association". 30 Oct 2009
• A dynamic oral cancer field: unraveling the underlying biology and its clinical implication. 30 Oct 2009
• Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. 30 Oct 2009
• TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility. 30 Oct 2009
• Clues to a life-threatening disease. 30 Oct 2009
• Genetic deficiencies of innate immune signalling in human infectious disease. 30 Oct 2009
• Anesthesia and pharmacogenomics: not ready for prime time. 30 Oct 2009

See a longer list of these articles.

Technical information about 'Genetic Predisposition to Disease'

Definition: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

Descriptor UI: D020022

Alternative terms: Genetic Predisposition to Disease; Predisposition, Genetic; Genetic Predispositions; Predispositions, Genetic; Susceptibility, Genetic; Genetic Susceptibilities; Susceptibilities, Genetic; Genetic Susceptibility; Genetic Predisposition;

Related Mesh Headings: Genetic Screening;

Allowable Qualifiers: classification; ethnology; embryology; epidemiology; etiology; genetics; history; prevention & control; psychology;

Tree Number: C23.550.291.687.500; G05.380.355;

History Note: 99

Technical Notes: latent susceptibility to dis only: coord with specific dis/genet; for positive genetic predisposition (like longevity) use specific trait/genet