Ginkgolides - Chemistry
Research News and Information

Sunday, November 22, 2009

[Preparation and characterization of solid dispersions of ginkgolides]

30 May 2009 OBJECTIVE: To optimize the preparation process of solid dispersions of ginkgolides to improve the drug dissolution. METHOD: The influence of formulation and preparation technology on drug release from solid dispersions was investigated by single ... Read more...

Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.

27 Feb 2009 Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry (LC/ESI-TOF-MS) and ultraperformance column liquid chromatographiclMS (UPLC/MS) methods were developed for the determination of 5 terpenelactones in the leaves of ... Read more...

Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals.

13 Jan 2009 The chemical analysis and quality control of Ginkgo leaves, extracts, phytopharmaceuticals and some herbal supplements is comprehensively reviewed. The review is an update of a similar, earlier review in this journal [T.A. van Beek, J. Chromatogr. A ... Read more...

Latest indexed articles for 'Ginkgolides - Chemistry'

These are the very latest articles for this heading:

• [Preparation and characterization of solid dispersions of ginkgolides] 30 May 2009
• Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements. 27 Feb 2009
• Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. 13 Jan 2009
• Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. 8 Jun 2008
• [Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method] 29 Apr 2008
• Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. 29 Apr 2008
• Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro. 28 Feb 2008
• Structure-activity analysis of ginkgolide binding in the glycine receptor pore. 19 Jan 2008
• Determination of the derivative from ginkgolide B. 30 Dec 2007
• Synthesis of novel ginkgolide photoaffinity--biotin probes. 17 Oct 2007
• Inhibitory effect of ginkgolide B on platelet aggregation in a cAMP- and cGMP-dependent manner by activated MMP-9. 28 Sep 2007
• Characterization of a suite of ginkgo-containing standard reference materials. 5 Jul 2007
• Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35). 2 Jul 2007
• Pharmacological action and mechanisms of ginkgolide B. 18 May 2007
• Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. 30 Mar 2007
• Probing the pharmacophore of ginkgolides as glycine receptor antagonists. 11 Mar 2007
• Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba. 8 Jul 2006
• Molecular determinants of ginkgolide binding in the glycine receptor pore. 29 Jun 2006
• Cloning and characterization of 2-C-methyl-D: -erythritol 2,4-cyclodiphosphate synthase (MECS) gene from Ginkgo biloba. 8 Mar 2006
• Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties. 30 Aug 2005

See a longer list of these articles.

Technical information about 'Ginkgolides'

Definition: DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.

Registry Number: 0

Descriptor UI: D046934

Alternative terms: Ginkgolides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.849.291.400;

History Note: 2005