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Ginkgolides - Pharmacokinetics
Research News and Information
Definition of 'Ginkgolides'DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES. Common names: Ginkgolides |
Sunday, November 22, 2009
9 Mar 2009 
A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats. An RT-PCR study further showed that mRNA expression of CYP2B was ... Read more...
27 Sep 2007 
The intestinal absorptive characteristics of ginkgolide B were investigated. The Caco-2 cells and the in situ closed loop were used as models of the intestinal mucosa to assess transepithelial transport of ginkgolide B. The determination of ... Read more...
Pharmacokinetics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats.
30 Dec 2006 Ginkgo B (GB) is an extract from the leaves of Ginkgo biloba, used in the treatment of dementia, cerebral insufficiency or related cognitive decline. In this paper, the main features of the pharmacokinetics of GB emulsion in rats were reviewed and ... Read more...
Latest indexed articles for 'Ginkgolides - Pharmacokinetics'
These are the very latest articles for this heading:
- Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
- Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method. 27 Sep 2007
- Pharmacokinetics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats. 30 Dec 2006
See a longer list of these articles.
Technical information about 'Ginkgolides'
Definition: DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.
Registry Number: 0
Descriptor UI: D046934
Alternative terms: Ginkgolides;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D02.455.849.291.400;
History Note: 2005