Ginkgolides - Pharmacology
Research News and Information

Monday, November 23, 2009

Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells.

30 Jul 2009 Ginkgolide B (GKB), the major active component of Ginkgo biloba extracts, can both stimulate and inhibit apoptotic signaling. We previously showed that ginkgolide treatment of mouse blastocysts induces apoptosis, decreases cell numbers, retards the ... Read more...

Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein.

29 Jun 2009 Atherosclerosis is a complex inflammatory arterial disease. Oxidized low-density lipoprotein (ox-LDL) is directly associated with chronic vascular inflammation. In the current study, we tested the hypothesis that ginkgolide B, a component of ... Read more...

Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects.

21 Jun 2009 Hypoxia and reoxygenation set in motion a series of events, including blood-brain barrier breakdown. We examined the content and effect of platelet-activating factor (PAF), which was increased in the rat brain microvessel endothelial cells (RBMECs) ... Read more...

Latest indexed articles for 'Ginkgolides - Pharmacology'

These are the very latest articles for this heading:

• Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. 30 Jul 2009
• Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein. 29 Jun 2009
• Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. 21 Jun 2009
• Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. 20 Jun 2009
• Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells. 19 May 2009
• Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
• Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury. 11 Dec 2008
• Effects of ginkgolide B on neuronal discharges in paraventricular nucleus of rat hypothalamic slices. 29 Nov 2008
• Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. 7 Oct 2008
• The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. 30 Aug 2008
• Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. 3 Aug 2008
• G[alpha]i2 and G[alpha]q expression change in pancreatic tissues and BN52021 effects in rats with severe acute pancreatitis. 30 Jul 2008
• Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals. 8 Jun 2008
• Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra. 29 Apr 2008
• Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. 29 Apr 2008
• A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. 23 Apr 2008
• Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. 30 Jan 2008
• Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. 29 Jan 2008
• Structure-activity analysis of ginkgolide binding in the glycine receptor pore. 19 Jan 2008
• Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes. 30 Dec 2007

See a longer list of these articles.

Technical information about 'Ginkgolides'

Definition: DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.

Registry Number: 0

Descriptor UI: D046934

Alternative terms: Ginkgolides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.849.291.400;

History Note: 2005