Ginkgolides
Research News and Information

Sunday, November 22, 2009

Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells.

30 Jul 2009 Ginkgolide B (GKB), the major active component of Ginkgo biloba extracts, can both stimulate and inhibit apoptotic signaling. We previously showed that ginkgolide treatment of mouse blastocysts induces apoptosis, decreases cell numbers, retards the ... Read more...

Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein.

29 Jun 2009 Atherosclerosis is a complex inflammatory arterial disease. Oxidized low-density lipoprotein (ox-LDL) is directly associated with chronic vascular inflammation. In the current study, we tested the hypothesis that ginkgolide B, a component of ... Read more...

Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects.

21 Jun 2009 Hypoxia and reoxygenation set in motion a series of events, including blood-brain barrier breakdown. We examined the content and effect of platelet-activating factor (PAF), which was increased in the rat brain microvessel endothelial cells (RBMECs) ... Read more...

Latest indexed articles for 'Ginkgolides'

These are the very latest articles for this heading:

• Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. 30 Jul 2009
• Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein. 29 Jun 2009
• Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. 21 Jun 2009
• Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans. 20 Jun 2009
• [Preparation and characterization of solid dispersions of ginkgolides] 30 May 2009
• Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells. 19 May 2009
• Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex. May 2009
• Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. 29 Apr 2009
• Ginkgo biloba prevention trials: more than an ounce of prevention learned. 29 Apr 2009
• Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2. 26 Apr 2009
• Injury effects of ginkgolide B on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo. 18 Mar 2009
• Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
• Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements. 27 Feb 2009
• Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. 13 Jan 2009
• [Assessment of efficacy and tolerance of tanakan during treatment of sensorineural bradyacuasia and tympanophonia] 30 Dec 2008
• Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury. 11 Dec 2008
• Effects of ginkgolide B on neuronal discharges in paraventricular nucleus of rat hypothalamic slices. 29 Nov 2008
• Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures. 12 Oct 2008
• Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. 7 Oct 2008
• The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. 30 Aug 2008

See a longer list of these articles.

Technical information about 'Ginkgolides'

Definition: DITERPENES with three LACTONES and a unique tert-butyl group, which are found in GINKGO plants along with BILOBALIDES.

Registry Number: 0

Descriptor UI: D046934

Alternative terms: Ginkgolides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.849.291.400;

History Note: 2005