Glial Cell Line-Derived Neurotrophic Factor
Research News and Information

Sunday, November 22, 2009

Role of glial cell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF.

7 Sep 2009 The formation of appropriate neuronal circuits is an essential part of nervous system development and relies heavily on the outgrowth of axons and dendrites and their guidance to their respective targets. This process is governed by a large array of ... Read more...

Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles.

30 Aug 2009 BACKGROUND: Nonviral gene therapy of chronic degenerative diseases such as Parkinson's disease (PD) is a great challenge as a result of the low tranfection efficiency of nonviral gene vectors. We previously constructed a lactoferrin (Lf)-modified ... Read more...

Increased levels of glial cell-derived neurotrophic factor in CSF of infants with SMA.

30 Aug 2009 The cause of motor neuron death in spinal muscular atrophy is still debated. In experimental animal models, neurotrophic factors have great potency in supporting motor neuron survival and differentiation, but there are no clinical studies on ... Read more...

Latest indexed articles for 'Glial Cell Line-Derived Neurotrophic Factor'

These are the very latest articles for this heading:

• Role of glial cell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF. 7 Sep 2009
• Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles. 30 Aug 2009
• Increased levels of glial cell-derived neurotrophic factor in CSF of infants with SMA. 30 Aug 2009
• GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. 13 Aug 2009
• GDNF expression in terminal schwann cells associated with the periodontal ruffini endings of the rat incisors during nerve regeneration. 30 Jul 2009
• Glial cell-derived neurotrophic factor increases migration of human chondrosarcoma cells via ERK and NF-kappaB pathways. 30 Jul 2009
• Cells therapy for Parkinson's disease--so close and so far away. 28 Jul 2009
• Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. 27 Jul 2009
• Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons. 13 Jul 2009
• GDNF blended chitosan nerve guides: an in vivo study. 29 Jun 2009
• Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. 29 Jun 2009
• Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease. 29 Jun 2009
• Functional RET G691S polymorphism in cutaneous malignant melanoma. 27 Jun 2009
• Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. 26 Jun 2009
• Quantitative analysis of multivesicular bodies (MVBs) in the hypoglossal nerve: evidence that neurotrophic factors do not use MVBs for retrograde axonal transport. 18 Jun 2009
• Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. 15 Jun 2009
• Hibernation-like state induced by an opioid peptide protects against experimental stroke. 15 Jun 2009
• Controlled release of glial-derived neurotrophic factor from fibrin matrices containing an affinity-based delivery system. 13 Jun 2009
• Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons. 10 Jun 2009
• Synergistic effect of GDNF and NGF on axonal branching and elongation in vitro. 9 Jun 2009

See a longer list of these articles.

Technical information about 'Glial Cell Line-Derived Neurotrophic Factor'

Definition: The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.

Registry Number: 0

Descriptor UI: D051100

Alternative terms: Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line Derived Neurotrophic Factor; GDNF Growth Factor; Growth Factor, GDNF; Glial Cell-Line Derived Neurotrophic Factor; GDNF;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.860.381.500; D12.776.467.860.381.500; D12.776.641.600.381.500; D23.529.850.381.500;

History Note: 2006(1993)

Technical Notes: GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS is also available