Glucocorticoids - Pharmacology
Research News and Information

Sunday, November 22, 2009

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.

18 Oct 2009 Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF ... Read more...

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.

7 Oct 2009 Common male reproductive abnormalities including cryptorchidism, hypospadias, and low sperm counts may comprise a testicular dysgenesis syndrome (TDS), resulting from fetal testis dysfunction during a critical developmental period involving reduced ... Read more...

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis.

3 Oct 2009 Circadian clock genes are regulated by glucocorticoids; however, whether this regulation is a direct or secondary effect and the physiological consequences of this regulation were unknown. Here, we identified glucocorticoid response elements (GREs) ... Read more...

Latest indexed articles for 'Glucocorticoids - Pharmacology'

These are the very latest articles for this heading:

• A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. 18 Oct 2009
• Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development. 7 Oct 2009
• Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. 3 Oct 2009
• Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. 29 Sep 2009
• Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1. 23 Sep 2009
• Enhancement of ligand-dependent down-regulation of glucocorticoid receptor by lipopolysaccharide. 31 Aug 2009
• Anti-vascular endothelial growth factor activity in the bevacizumab and triamcinolone acetonide combination for intravitreal use. 30 Aug 2009
• A pilot study comparing the diabetogenic effects of dexamethasone and prednisolone in cats. 30 Aug 2009
• Antenatal corticosteroids increase fetal, but not postnatal, pulmonary blood flow in sheep. 30 Aug 2009
• Efficacy of ophthalmic nonsteroidal antiinflammatory drugs in suppressing anterior capsule contraction and secondary posterior capsule opacification. 30 Aug 2009
• Therapeutic targets for new therapy for corticosteroid refractory asthma. 30 Aug 2009
• Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. 30 Aug 2009
• Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease. 30 Aug 2009
• Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. 25 Aug 2009
• Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation. 22 Aug 2009
• Amphetamine reduces vesicular dopamine content in dexamethasone-differentiated PC12 cells only following L-DOPA exposure. 20 Aug 2009
• Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats. 5 Aug 2009
• Endotoxin depresses heart rate variability in mice: cytokine and steroid effects. 3 Aug 2009
• The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus. 30 Jul 2009
• [Effect on transforming growth factor-beta1 of glucocorticoid-induced avascular necrosis of femoral head in rats by treatment of activating blood circulation of Chinese herbal medicine] 30 Jul 2009

See a longer list of these articles.

Technical information about 'Glucocorticoids'

Definition: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Registry Number: 0

Descriptor UI: D005938

Alternative terms: Glucocorticoids;

Related Mesh Headings: Receptors, Glucocorticoid;

Allowable Qualifiers: blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis;

Tree Number: D06.472.040.543; D27.505.696.399.472.488;

History Note: 67

Technical Notes: GEN: avoid: prefer specifics;