Glutamate Decarboxylase - Genetics
Research News and Information

Sunday, November 22, 2009

Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination.

12 Sep 2009 Tissue-specific autoimmune diseases such as type 1 diabetes (T1D) are characterized by T cell-driven pathology. Administration of autoantigenic peptides provides a strategy to selectively target the pathogenic T cell response. Indeed, treatment with ... Read more...

Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats.

25 Aug 2009 We investigated the effect of early vs. late initiation of levodopa treatment on dyskinetic movements, rotational behavior and molecular markers in hemiparkinsonian rats. Male Sprague-Dawley rats received a unilateral 6-hydroxydopamine (6-OHDA) ... Read more...

Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.

24 Aug 2009 Inhibitory interneurons are crucially important for cerebral cortex function and behavior. The mechanisms controlling inhibitory interneuron diversification and allocation to distinct cortical areas remain poorly understood. GDNF (glial cell ... Read more...

Latest indexed articles for 'Glutamate Decarboxylase - Genetics'

These are the very latest articles for this heading:

• Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. 12 Sep 2009
• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. 24 Aug 2009
• DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. 24 Aug 2009
• Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. 24 Aug 2009
• Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia. 3 Aug 2009
• SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. 3 Aug 2009
• Cloning and expression of glutamate decarboxylase gene from Streptococcus thermophilus Y2. 30 Jul 2009
• Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development. 30 Jul 2009
• GABAergic neuron distribution in the pedunculopontine nucleus defines functional subterritories. 30 Jul 2009
• Expression and distribution of GABAergic system in rat knee joint synovial membrane. 30 Jul 2009
• Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2. 26 Jul 2009
• Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. 18 Jul 2009
• The gad2 promoter is a transcriptional target of estrogen receptor (ER)alpha and ER beta: a unifying hypothesis to explain diverse effects of estradiol. 6 Jul 2009
• Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65. 29 Jun 2009
• Dynamic regulation of glutamic acid decarboxylase 65 gene expression in rat testis. 29 Jun 2009
• Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. 29 Jun 2009
• Epigenetic mechanisms in schizophrenia. 23 Jun 2009
• Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. 15 Jun 2009
• A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. Jun 2009

See a longer list of these articles.

Technical information about 'Glutamate Decarboxylase'

Definition: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

Chemical name: L-Glutamate-1-carboxy-lyase

Registry Number: EC 4.1.1.15

Descriptor UI: D005968

Alternative terms: Glutamate Decarboxylase; Decarboxylase, Glutamate; Glutamic Acid Decarboxylase; Acid Decarboxylase, Glutamic; Decarboxylase, Glutamic Acid; Glutamate Carboxy-Lyase; Carboxy-Lyase, Glutamate; Glutamate Carboxy Lyase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.520.224.125.250;

History Note: 84(75); was see under CARBOXY-LYASES 1975-83