Glutamate Decarboxylase - Metabolism
Research News and Information

Sunday, November 22, 2009

The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods.

18 Oct 2009 We used in situ hybridization on sections to examine the distribution of GAD67-expressing cell populations in the entire forebrain of the adult zebrafish. GAD67 is predominantly expressed in the olfactory bulb (OB), all regions of the subpallium ... Read more...

Associative pairing involving monocular stimulation selectively mobilizes a subclass of GABAergic interneurons in the mouse visual cortex.

18 Oct 2009 Levels of gamma-aminobutyric acid (GABA) and its synthesizing enzyme in cerebral cortex are regulated by sensory experience. Previously we found that associative pairing of vibrissae stimulation and tail shock results in upregulation of GABAergic ... Read more...

Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle.

21 Sep 2009 Whereas basal forebrain (BF) cholinergic neurons are known to participate in processes of cortical activation during wake (W) and paradoxical sleep (PS or P, also called REM sleep), codistributed GABAergic neurons have been thought to participate in ... Read more...

Latest indexed articles for 'Glutamate Decarboxylase - Metabolism'

These are the very latest articles for this heading:

• The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. 18 Oct 2009
• Associative pairing involving monocular stimulation selectively mobilizes a subclass of GABAergic interneurons in the mouse visual cortex. 18 Oct 2009
• Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle. 21 Sep 2009
• Immunohistochemical study of pig retinal development. 19 Sep 2009
• Spontaneous activity in the developing mouse midbrain driven by an external pacemaker. 13 Sep 2009
• A developmental approach to forebrain organization in elasmobranchs: new perspectives on the regionalization of the telencephalon. 31 Aug 2009
• DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. 24 Aug 2009
• Glutamatergic cerebellar granule neurons synthesize and secrete reelin in vitro. 11 Aug 2009
• GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways. 3 Aug 2009
• Cloning and expression of glutamate decarboxylase gene from Streptococcus thermophilus Y2. 30 Jul 2009
• Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development. 30 Jul 2009
• Perisomatic-targeting granule cells in the mouse olfactory bulb. 30 Jul 2009
• GABAergic neuron distribution in the pedunculopontine nucleus defines functional subterritories. 30 Jul 2009
• Expression and distribution of GABAergic system in rat knee joint synovial membrane. 30 Jul 2009
• Olfactory enrichment influences adult neurogenesis modulating GAD67 and plasticity-related molecules expression in newborn cells of the olfactory bulb. 21 Jul 2009
• Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. 18 Jul 2009
• Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cord. 15 Jul 2009
• MK801-induced activated caspase-3 exhibits selective co-localization with GAD67. 7 Jul 2009
• The gad2 promoter is a transcriptional target of estrogen receptor (ER)alpha and ER beta: a unifying hypothesis to explain diverse effects of estradiol. 6 Jul 2009
• A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. 2 Jul 2009

See a longer list of these articles.

Technical information about 'Glutamate Decarboxylase'

Definition: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

Chemical name: L-Glutamate-1-carboxy-lyase

Registry Number: EC 4.1.1.15

Descriptor UI: D005968

Alternative terms: Glutamate Decarboxylase; Decarboxylase, Glutamate; Glutamic Acid Decarboxylase; Acid Decarboxylase, Glutamic; Decarboxylase, Glutamic Acid; Glutamate Carboxy-Lyase; Carboxy-Lyase, Glutamate; Glutamate Carboxy Lyase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.520.224.125.250;

History Note: 84(75); was see under CARBOXY-LYASES 1975-83