Glutamate Decarboxylase
Research News and Information

Tuesday, November 24, 2009

Two classes of GABAergic neurons in the inferior colliculus.

2 Nov 2009 The inferior colliculus (IC) is unique, having both glutamatergic and GABAergic projections ascending to the thalamus. Although subpopulations of GABAergic neurons in the IC have been proposed, criteria to distinguish them have been elusive and ... Read more...

The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods.

18 Oct 2009 We used in situ hybridization on sections to examine the distribution of GAD67-expressing cell populations in the entire forebrain of the adult zebrafish. GAD67 is predominantly expressed in the olfactory bulb (OB), all regions of the subpallium ... Read more...

Associative pairing involving monocular stimulation selectively mobilizes a subclass of GABAergic interneurons in the mouse visual cortex.

18 Oct 2009 Levels of gamma-aminobutyric acid (GABA) and its synthesizing enzyme in cerebral cortex are regulated by sensory experience. Previously we found that associative pairing of vibrissae stimulation and tail shock results in upregulation of GABAergic ... Read more...

Latest indexed articles for 'Glutamate Decarboxylase'

These are the very latest articles for this heading:

• Two classes of GABAergic neurons in the inferior colliculus. 2 Nov 2009
• The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. 18 Oct 2009
• Associative pairing involving monocular stimulation selectively mobilizes a subclass of GABAergic interneurons in the mouse visual cortex. 18 Oct 2009
• Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. 30 Sep 2009
• Discharge profiles of identified GABAergic in comparison to cholinergic and putative glutamatergic basal forebrain neurons across the sleep-wake cycle. 21 Sep 2009
• Immunohistochemical study of pig retinal development. 19 Sep 2009
• Spontaneous activity in the developing mouse midbrain driven by an external pacemaker. 13 Sep 2009
• Interferon beta treatment does not induce organ-specific autoantibodies in multiple sclerosis. 13 Sep 2009
• Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. 12 Sep 2009
• A developmental approach to forebrain organization in elasmobranchs: new perspectives on the regionalization of the telencephalon. 31 Aug 2009
• Finding our way: diagnostic perils and the stiff person syndrome. 30 Aug 2009
• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling. 24 Aug 2009
• DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. 24 Aug 2009
• Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. 24 Aug 2009
• Glutamatergic cerebellar granule neurons synthesize and secrete reelin in vitro. 11 Aug 2009
• Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia. 3 Aug 2009
• SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. 3 Aug 2009
• GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways. 3 Aug 2009
• Cloning and expression of glutamate decarboxylase gene from Streptococcus thermophilus Y2. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Glutamate Decarboxylase'

Definition: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

Chemical name: L-Glutamate-1-carboxy-lyase

Registry Number: EC 4.1.1.15

Descriptor UI: D005968

Alternative terms: Glutamate Decarboxylase; Decarboxylase, Glutamate; Glutamic Acid Decarboxylase; Acid Decarboxylase, Glutamic; Decarboxylase, Glutamic Acid; Glutamate Carboxy-Lyase; Carboxy-Lyase, Glutamate; Glutamate Carboxy Lyase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.520.224.125.250;

History Note: 84(75); was see under CARBOXY-LYASES 1975-83