Glyburide
Research News and Information

Monday, November 23, 2009

Mechanisms of impaired glucose tolerance and insulin secretion during isoflurane anesthesia.

30 Oct 2009 BACKGROUND: Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown. The authors hypothesized that isoflurane inhibits glucose-induced inhibition of ... Read more...

The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.

30 Oct 2009 BACKGROUND: Propofol (2,6-diisopropylphenol) has been shown to protect several organs, including the kidneys, from ischemia-reperfusion (I-R)-induced injury. Although propofol affects adenosine triphosphate-sensitive potassium (K(ATP)) channels in ... Read more...

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

3 Oct 2009 Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular ... Read more...

Latest indexed articles for 'Glyburide'

These are the very latest articles for this heading:

• Mechanisms of impaired glucose tolerance and insulin secretion during isoflurane anesthesia. 30 Oct 2009
• The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. 30 Oct 2009
• Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. 3 Oct 2009
• Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector. 29 Sep 2009
• Selecting among ADA/EASD tier 1 and tier 2 treatment options. 30 Aug 2009
• Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. 13 Aug 2009
• The use of oral antidiabetic medications in gestational diabetes mellitus. 30 Jul 2009
• The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. 29 Jul 2009
• Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling. 13 Jul 2009
• Improved diabetic control during oral sulfonylurea treatment in two children with permanent neonatal diabetes mellitus. 29 Jun 2009
• Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus. 29 Jun 2009
• NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs. 25 Jun 2009
• Low-dose pioglitazone increases serum high molecular weight adiponectin and improves glycemic control in Japanese patients with poorly controlled type 2 diabetes. 19 Jun 2009
• Comparative roles of ATP-sensitive K+ channels and Ca2+-activated BK+ channels in posthypoxic hyperexcitability and rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro. 15 Jun 2009
• Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. 13 Jun 2009
• Adipocyte-derived factor reduces vasodilatory capability in ob-/ob- mice. 3 Jun 2009
• Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha. Jun 2009
• Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons. 31 May 2009
• Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. 30 May 2009
• Outbreak of hypoglycaemia: sexual enhancement products containing oral hypoglycaemic agent. 30 May 2009

See a longer list of these articles.

Technical information about 'Glyburide'

Definition: An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

Chemical name: Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-

Registry Number: 10238-21-8

Descriptor UI: D005905

Alternative terms: Glyburide; Glybenclamide; Glibenclamide; Diabeta; Euglucon 5; Neogluconin; HB-419; HB 419; HB419; HB-420; HB 420; HB420; Maninil; Micronase; Daonil; Euglucon N;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hypoglycemic Agents;

Tree Number: D02.886.590.795.575; D02.948.828.575;

Online Note: use GLYBURIDE to search GLIBENCLAMIDE 1971-91 (as Prov 1971-72)

History Note: 92; was GLIBENCLAMIDE 1971-91 (Prov 1971-72); GLYBURIDE was see GLIBENCLAMIDE 1973-91