GTP-Binding Protein alpha Subunit, Gi2 - Genetics
Research News and Information

Monday, November 23, 2009

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

30 Oct 2009 BACKGROUND: Recent evidence suggests that G protein-coupled receptors, especially those linked to G(alpha)(i), contribute to the mechanisms of anesthetic action. Regulator of G protein signaling (RGS) proteins bind to activated G(alpha)(i) and ... Read more...

Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.

26 Jul 2009 Sporadic human mismatch repair (MMR)-deficient colorectal cancers account for approximately 12.5% of all cases of colorectal cancer. MMR-deficient colorectal cancers are classically characterized by right-sided location, multifocality, mucinous ... Read more...

Intestinal mucosal inflammation leads to systemic genotoxicity in mice.

30 May 2009 Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, substantially increases the risk of colorectal cancer. However, mechanisms linking mucosal inflammation to the sequence of dysplasia are incompletely understood. Whereas ... Read more...

Latest indexed articles for 'GTP-Binding Protein alpha Subunit, Gi2 - Genetics'

These are the very latest articles for this heading:

• Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. 30 Oct 2009
• More damaging than we think: systemic effects of intestinal inflammation. 13 Aug 2009
• Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. 26 Jul 2009
• Intestinal mucosal inflammation leads to systemic genotoxicity in mice. 30 May 2009
• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. 6 May 2009
• Alterations in myeloid dendritic cell innate immune responses in the Galphai2-deficient mouse model of colitis. 30 Jan 2009
• An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. 29 Nov 2008
• Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. 18 Oct 2008
• The specific activation of TRPC4 by Gi protein subtype. 10 Oct 2008
• Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2. 30 Sep 2008
• G[alpha]i2 and G[alpha]q expression change in pancreatic tissues and BN52021 effects in rats with severe acute pancreatitis. 30 Jul 2008
• Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. 8 Jul 2008
• TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. 5 May 2008
• Activation of caspase-3 pathway by expression of sGalphai2 protein in BHK cells. 23 Apr 2008
• Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Mar 2008
• Xenopus V1R vomeronasal receptor family is expressed in the main olfactory system. 29 Jan 2008
• RIG-I has guts: identification of a role for RIG-I in colitis development. 29 Nov 2007
• A fresh look at an antiviral helicase. 30 Oct 2007
• Hormonal regulation of Galphai2 and mPRalpha in immortalized human oviductal cell line OE-E6/E7. 29 Oct 2007

See a longer list of these articles.

Technical information about 'GTP-Binding Protein alpha Subunit, Gi2'

Definition: A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.

Registry Number: EC 3.6.1.46

Descriptor UI: D051960

Alternative terms: GTP-Binding Protein alpha Subunit, Gi2; GTP Binding Protein alpha Subunit, Gi2; Galpha(i2) Protein; Gi2-alpha Protein; Gi2 alpha Protein; G Protein Subunit alpha I2; Galphai2 Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D08.811.277.040.330.300.200.100.200.500; D12.644.360.375.100.200.500; D12.776.157.325.332.100.200.500; D12.776.476.375.100.200.500; D12.776.543.325.100.200.500;

History Note: 2006(1993)