GTP-Binding Protein alpha Subunit, Gi2 - Metabolism
Research News and Information

Sunday, November 22, 2009

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

30 Oct 2009 BACKGROUND: Recent evidence suggests that G protein-coupled receptors, especially those linked to G(alpha)(i), contribute to the mechanisms of anesthetic action. Regulator of G protein signaling (RGS) proteins bind to activated G(alpha)(i) and ... Read more...

Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

17 Jun 2009 Despite extensive characterization of the mu-opioid receptor (MOR), the biochemical properties of the isolated receptor remain unclear. In light of recent reports, we proposed that the monomeric form of MOR can activate G proteins and be subject to ... Read more...

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.

26 May 2009 Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of the disease. Here we describe a mouse model of an anxiety/depressive-like state induced ... Read more...

Latest indexed articles for 'GTP-Binding Protein alpha Subunit, Gi2 - Metabolism'

These are the very latest articles for this heading:

• Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. 30 Oct 2009
• Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. 17 Jun 2009
• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. 6 May 2009
• GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. 15 Mar 2009
• The rapid activation of N-Ras by alpha-thrombin in fibroblasts is mediated by the specific G-protein Galphai2-Gbeta1-Ggamma5 and occurs in lipid rafts. 25 Feb 2009
• An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. 29 Nov 2008
• Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. 22 Nov 2008
• Heterogeneities of size and sexual dimorphism between the subdomains of the lateral-innervated accessory olfactory bulb (AOB) of Octodon degus (Rodentia: Hystricognathi). 10 Nov 2008
• Identification of G protein alpha subunit-palmitoylating enzyme. 8 Nov 2008
• Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. 18 Oct 2008
• The specific activation of TRPC4 by Gi protein subtype. 10 Oct 2008
• Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein G(alpha)i2beta1gamma2. 30 Sep 2008
• The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. 29 Sep 2008
• Rats with monosodium glutamate-induced obesity and insulin resistance exhibit low expression of Galpha(i2) G-protein. 30 Aug 2008
• G[alpha]i2 and G[alpha]q expression change in pancreatic tissues and BN52021 effects in rats with severe acute pancreatitis. 30 Jul 2008
• Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. 8 Jul 2008
• Agonist-selective signaling is determined by the receptor location within the membrane domains. 29 Jun 2008
• Requirement of Galphai in thymic homing and early T cell development. 21 May 2008
• Signaling by dopamine regulates D2 receptors trafficking at the membrane. 13 May 2008

See a longer list of these articles.

Technical information about 'GTP-Binding Protein alpha Subunit, Gi2'

Definition: A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.

Registry Number: EC 3.6.1.46

Descriptor UI: D051960

Alternative terms: GTP-Binding Protein alpha Subunit, Gi2; GTP Binding Protein alpha Subunit, Gi2; Galpha(i2) Protein; Gi2-alpha Protein; Gi2 alpha Protein; G Protein Subunit alpha I2; Galphai2 Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D08.811.277.040.330.300.200.100.200.500; D12.644.360.375.100.200.500; D12.776.157.325.332.100.200.500; D12.776.476.375.100.200.500; D12.776.543.325.100.200.500;

History Note: 2006(1993)