 |
Heat-Shock Proteins - Antagonists & inhibitors
Research News and Information
Definition of 'Heat-Shock Proteins'Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions. Common names: Heat-Shock Proteins; Heat Shock Proteins; Proteins, Heat-Shock; Stress Proteins; Proteins, Stress; Heat-Shock Protein; Heat Shock Protein; Protein, Heat-Shock; Stress Protein 71; Protein 71, Stress; Stress Protein 34; Protein 34, Stress; Heat-Shock Protein Chlamydomonas |
Sunday, November 22, 2009
[Molecular-targeted therapy for motor neuron disease]
30 Jul 2009 
The mechanisms underlying selective motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remain unknown. There have been several important clinical trials on the treatment of ALS and treatment efficacy studies using mouse (SOD1) models ... Read more...
The role of heat shock proteins in gastrointestinal diseases.
29 Jun 2009 Heat shock proteins (HSPs) are a highly conserved family of proteins which inhabit almost all subcellular locations and cellular membranes. Depending on their location, these proteins perform a variety of chaperoning functions including folding of ... Read more...
19 Apr 2009 The heat shock protein (HSP) 90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in clinical trials because of its unique mechanism of action and antitumor activity. However, 17-AAG triggers the transcription and elevation of ... Read more...
Latest indexed articles for 'Heat-Shock Proteins - Antagonists & inhibitors'
These are the very latest articles for this heading:
- [Molecular-targeted therapy for motor neuron disease] 30 Jul 2009
- The role of heat shock proteins in gastrointestinal diseases. 29 Jun 2009
- Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d. 19 Apr 2009
- Novel targeted agents for lung cancer. 27 Feb 2009
- New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6. 24 Feb 2009
- Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. 10 Feb 2009
- Selectivity profiling of DegP substrates and inhibitors. 3 Feb 2009
- Heat shock protein inhibitors and vaccines as new agents in cancer treatment. 30 Jan 2009
- Heat shock proteins in cancer: signaling pathways, tumor markers and molecular targets in liver malignancy. 30 Dec 2008
- Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells.
15 Dec 2008 - Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. 9 Dec 2008
- A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6. 29 Nov 2008
- Enhanced recovery from contraction-induced damage in skeletal muscles of old mice following treatment with the heat shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin. 29 Nov 2008
- New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. 29 Nov 2008
- A proteomic approach to identifying new drug targets (potentiating topoisomerase II poisons). 29 Sep 2008
- Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response. 15 Sep 2008
- P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response. 13 Sep 2008
- Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. 30 Jul 2008
- Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells. 8 Jul 2008
- Proteomic analysis of hypoxia-induced tube breakdown of an in vitro capillary model composed of HUVECs: potential role of p38-regulated reduction of HSP27. 29 Jun 2008
See a longer list of these articles.
Technical information about 'Heat-Shock Proteins'
Definition: Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
Registry Number: 0
Descriptor UI: D006360
Alternative terms: Heat-Shock Proteins; Heat Shock Proteins; Proteins, Heat-Shock; Stress Proteins; Proteins, Stress; Heat-Shock Protein; Heat Shock Protein; Protein, Heat-Shock; Stress Protein 71; Protein 71, Stress; Stress Protein 34; Protein 34, Stress; Heat-Shock Protein Chlamydomonas; Chlamydomonas, Heat-Shock Protein; Heat Shock Protein Chlamydomonas;
Related Mesh Headings: Molecular Chaperones;
Allowable Qualifiers: economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects;
Tree Number: D12.776.410;
History Note: 84
Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted; do not use /analogs