Hematopoietic Stem Cells - Drug effects
Research News and Information

Monday, November 23, 2009

Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.

13 Oct 2009 Human CD34(+) hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in these cultures has not been studied in detail. Since these ... Read more...

The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.

30 Aug 2009 It was unknown if a mitochondria-targeted nitroxide (JP4-039) could augment potentially lethal damage repair (PLDR) of cells in quiescence. We evaluated 32D cl 3 murine hematopoietic progenitor cells which were irradiated and then either centrifuged ... Read more...

DNA synthesis of rat bone marrow mesenchymal stem cells through alpha1-adrenergic receptors.

16 Aug 2009 Multipotential bone marrow mesenchymal stem cells (BMSCs) are important in maintaining the microenvironment of the bone marrow (BM). Sympathetic nerves histologically innervate the BM; however, their role remains unclear. In this study, the effects ... Read more...

Latest indexed articles for 'Hematopoietic Stem Cells - Drug effects'

These are the very latest articles for this heading:

• Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. 13 Oct 2009
• Rendering the leukemia cell susceptible to attack. 22 Sep 2009
• Developmental biology: Instructions writ in blood. 8 Sep 2009
• The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. 30 Aug 2009
• DNA synthesis of rat bone marrow mesenchymal stem cells through alpha1-adrenergic receptors. 16 Aug 2009
• Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. 2 Aug 2009
• Ligation of CD44 with low-molecular-weight hyaluronan and a monoclonal antibody leads to inhibition of drug-induced apoptosis in a human myeloid cell line. 30 Jul 2009
• Dextran sulfate and stromal cell derived factor-1 promote CXCR4 expression and improve bone marrow homing efficiency of infused hematopoietic stem cells. 30 Jul 2009
• Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures. 12 Jul 2009
• Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells. 6 Jul 2009
• Valproic acid increases CXCR4 expression in hematopoietic stem/progenitor cells by chromatin remodeling. 29 Jun 2009
• Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia. 28 Jun 2009
• Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation. 24 Jun 2009
• Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. 23 Jun 2009
• Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. 15 Jun 2009
• The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). 8 Jun 2009
• Role of the spleen in cyclophosphamide-induced hematosuppression and extramedullary hematopoiesis in mice. 2 Jun 2009
• Prospects for gene therapy of osteopetrosis. 30 May 2009
• A role for the renin-angiotensin system in hematopoiesis. 30 May 2009
• Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. 30 May 2009

See a longer list of these articles.

Technical information about 'Hematopoietic Stem Cells'

Definition: Progenitor cells from which all blood cells derive.

Descriptor UI: D006412

Alternative terms: Hematopoietic Stem Cells; Progenitor Cells, Hematopoietic; Hematopoietic Progenitor Cells; Cell, Hematopoietic Progenitor; Cells, Hematopoietic Progenitor; Hematopoietic Progenitor Cell; Progenitor Cell, Hematopoietic; Stem Cells, Hematopoietic; Cell, Hematopoietic Stem; Cells, Hematopoietic Stem; Hematopoietic Stem Cell; Stem Cell, Hematopoietic; Colony-Forming Units, Hematopoietic; Colony Forming Units, Hematopoietic; Colony-Forming Unit, Hematopoietic; Hematopoietic Colony-Forming Unit; Hematopoietic Colony-Forming Units; Unit, Hematopoietic Colony-Forming; Units, Hematopoietic Colony-Forming;

Related Mesh Headings: Colony-Forming Units Assay;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.148.378; A11.872.378; A15.378.316.378;

History Note: 72(71)

Technical Notes: A 11 qualif; /transpl = HEMATOPOIETIC STEM CELL TRANSPLANTATION