Hemophilia A - Drug therapy
Research News and Information

Monday, November 23, 2009

Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice.

2 Aug 2009 Recombinant FVIII formulated in PEG-ylated liposomes (rFVIII-PEG-Lip) was reported to increase the bleed-free days from 7 to 13 days (at 35 IU/kg rFVIII) in severe hemophilia A patients. To understand the underlying mechanism, we sought to ... Read more...

Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies.

30 Jul 2009 About 30 % of patients with severe hemophilia A develop neutralizing antibodies (inhibitors) to coagulation factor VIII (FVIII) upon treatment with exogenous factor preparations. Two peptides, C6 (NPVENMMDRDSQ) and H10 (QSPWQTWFTRAL), that mimic ... Read more...

A rapidly progressive, life-threatening postpartum hemorrhage: successful treatment with anti-CD-20 monoclonal antibody.

30 Jul 2009 BACKGROUND: Postpartum hemorrhage may be a life-threatening event and may result from coagulation defects. CASE: We report a case of a multigravida woman who developed rapidly progressive postpartum bleeding as a result of acquired factor VIII ... Read more...

Latest indexed articles for 'Hemophilia A - Drug therapy'

These are the very latest articles for this heading:

• [89-year-old woman with hemorrhagic diathesis] 14 Sep 2009
• Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice. 2 Aug 2009
• Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies. 30 Jul 2009
• A rapidly progressive, life-threatening postpartum hemorrhage: successful treatment with anti-CD-20 monoclonal antibody. 30 Jul 2009
• [Place of recombinant activated factor VII in the treatment of severe haemorrhage in paediatric patients] 29 Jun 2009
• The comparative immunogenicity of human and porcine factor VIII in haemophilia A mice. 29 Jun 2009
• Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses. 21 Jun 2009
• Factor VIII-von Willebrand factor binding defects in autosomal recessive von Willebrand disease type Normandy and in mild hemophilia A. New insights into factor VIII-von Willebrand factor interactions. 6 Jun 2009
• Successful treatment with rituximab in an elderly patient with acquired factor VIII inhibitor. 30 May 2009
• Therapeutic properties and safety of recombinant factor VIII and factor IX. 30 May 2009
• Intensive peri-operative use of factor VIII and the Arg593-->Cys mutation are risk factors for inhibitor development in mild/moderate hemophilia A. 30 May 2009
• Acquired hemophilia A with sigmoid colon cancer: successful treatment with rituximab followed by sigmoidectomy. 28 May 2009
• Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice. 29 Apr 2009
• Quantifying the source of infection for HIV-infected hemophiliacs in the U.K. from 1979 to 1984. 29 Apr 2009
• [Relevance of a single dose of 270 microg/kg recombinant factor VIIa for the treatment of patients with haemophilia and inhibitors - Recommendations from the GTH experts] 29 Apr 2009
• Inhibitor treatment by rituximab in congenital haemophilia A - Two case reports. 29 Apr 2009
• Spontaneous disappearance of high titre factor VIII inhibitor 15 years after unsuccessful ITI. 29 Apr 2009
• Bacterial endocarditis and septic arthritis in a patient with severe hemophilia A: a case report. 29 Apr 2009
• The role of tissue factor and factor VIIa in hemostasis. 29 Apr 2009
• Characterization of a novel mutation in the F8 promoter region associated with mild hemophilia A and resistance to DDAVP therapy. 28 Apr 2009

See a longer list of these articles.

Technical information about 'Hemophilia A'

Definition: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.

Descriptor UI: D006467

Alternative terms: Hemophilia A; A, Hemophilia; As, Hemophilia; Hemophilia As; Haemophilia; Factor VIII Deficiency; Hemophilia; Deficiency, Factor VIII; Deficiencies, Factor VIII; Factor VIII Deficiencies;

Related Mesh Headings: Hemophilia B; Hemarthrosis;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C15.378.100.100.500; C15.378.100.141.500; C15.378.463.500; C16.320.099.500;

History Note: 99(66)