Heparitin Sulfate - Metabolism
Research News and Information

Sunday, November 22, 2009

Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.

21 Oct 2009 The plasminogen/plasmin system is involved in a variety of normal physiological and pathological processes, including tissue remodelling, angiogenesis and tumour metastasis. Plasminogen activators and receptors for plasminogen/plasminogen activators ... Read more...

The molecular basis and functional implications of chemokine interactions with heparan sulphate.

28 Sep 2009 The ability of cells to migrate in response to chemokine mediated signals, a process known as chemotaxis, is fundamental in the context of inflammation, as in many other physiological processes. Chemokines binding to heparan sulphate ensures their ... Read more...

Selective filtering of particles by the extracellular matrix: an electrostatic bandpass.

14 Sep 2009 The transport of microscopic particles such as growth factors, proteins, or drugs through the extracellular matrix (ECM) is based on diffusion, a ubiquitous mechanism in nature. The ECM shapes the local distribution of the transported macromolecules ... Read more...

Latest indexed articles for 'Heparitin Sulfate - Metabolism'

These are the very latest articles for this heading:

• Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage. 21 Oct 2009
• The molecular basis and functional implications of chemokine interactions with heparan sulphate. 28 Sep 2009
• Selective filtering of particles by the extracellular matrix: an electrostatic bandpass. 14 Sep 2009
• Toward an artificial Golgi: redesigning the biological activities of heparan sulfate on a digital microfluidic chip. 10 Aug 2009
• Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain. 5 Aug 2009
• High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease. 29 Jul 2009
• Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. 11 Jul 2009
• Identification of neutralizing conformational epitopes on the human papillomavirus type 31 major capsid protein and functional implications. 29 Jun 2009
• Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. 27 Jun 2009
• Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch. 21 Jun 2009
• The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells. 13 Jun 2009
• Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution. 7 Jun 2009
• Structure and functional relevance of the Slit2 homodimerization domain. 3 Jun 2009
• Human C21orf63 is a heparin-binding protein. 24 May 2009
• Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2. 25 Apr 2009
• Peripheral mural cell recruitment requires cell-autonomous heparan sulfate. 25 Apr 2009
• The signal peptide of Staphylococcus aureus panton valentine leukocidin LukS component mediates increased adhesion to heparan sulfates. 4 Apr 2009
• Distribution of extracellular matrix components in normal and degenerated canine tricuspid valve leaflets. 30 Mar 2009
• A biophysical insight into the RANTES-glycosaminoglycan interaction. 30 Mar 2009
• Important role of heparan sulfate in postnatal islet growth and insulin secretion. 27 Mar 2009

See a longer list of these articles.

Technical information about 'Heparitin Sulfate'

Definition: A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.

Chemical name: Heparitin, sulfate

Registry Number: 9050-30-0

Descriptor UI: D006497

Alternative terms: Heparitin Sulfate; Sulfate, Heparitin; Heparan Sulfate; Sulfate, Heparan;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; ultrastructure;

Tree Number: D09.698.373.425;

History Note: 91(72); was see under MUCOPOLYSACCHARIDES 1972-90

Technical Notes: do not confuse X ref HEPARAN SULFATE with HEPARAN SULFATE PROTEOGLYCANS