High Mobility Group Proteins
Research News and Information

Sunday, March 21, 2010

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

2 Sep 2009 Specialized topoisomerases solve the topological constraints arising when replication forks encounter transcription. We have investigated the contribution of Top2 in S phase transcription. Specifically in S phase, Top2 binds intergenic regions close ... Read more...

p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.

18 Aug 2009 RATIONALE: Exercise capacity is a physiological characteristic associated with protection from both cardiovascular and all-cause mortality. p53 regulates mitochondrial function and its deletion markedly diminishes exercise capacity, but the ... Read more...

yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement.

12 Aug 2009 FACT has been proposed to function by displacing H2A-H2B dimers from nucleosomes to form hexasomes. Results described here with yeast FACT (yFACT) suggest instead that nucleosomes are reorganized to a form with the original composition but a looser, ... Read more...

Latest indexed articles for 'High Mobility Group Proteins'

These are the very latest articles for this heading:

• Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. 2 Sep 2009
• p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. 18 Aug 2009
• yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. 12 Aug 2009
• PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. 30 Jul 2009
• Knockout of p47 phox uncovers a critical role of p40 phox in reactive oxygen species production in microvascular endothelial cells. 14 Jul 2009
• Phosphorylated intrinsically disordered region of FACT masks its nucleosomal DNA binding elements. 13 Jul 2009
• FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. 29 Jun 2009
• Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. 30 May 2009
• Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. 16 May 2009
• FACT and Asf1 regulate nucleosome dynamics and coactivator binding at the HO promoter. 12 May 2009
• Keys to open chromatin for transcription activation: FACT and Asf1. 12 May 2009
• Evaluating precision and accuracy when quantifying different endogenous control reference genes in maize using real-time PCR. 6 Apr 2009
• DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT. 30 Mar 2009
• RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. 15 Mar 2009
• Application of high-mobility-group-A proteins increases the proliferative activity of chondrocytes in vitro. 27 Feb 2009
• The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. 27 Feb 2009
• FACT facilitates chromatin transcription by RNA polymerases I and III. 10 Feb 2009
• The dynamics of HMG protein-chromatin interactions in living cells. 30 Jan 2009
• Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae. 29 Jan 2009
• CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway. 27 Jan 2009

See a longer list of these articles.

Technical information about 'High Mobility Group Proteins'

Definition: A family of low-molecular weight, non-histone proteins found in chromatin.

Registry Number: 0

Descriptor UI: D006609

Alternative terms: High Mobility Group Proteins; HMG Proteins; High Mobility Group Chromosomal Proteins; Calf Thymus Chromatin Protein HMG;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.660.235.400; D12.776.664.235.400;

History Note: 85

Technical Notes: GEN or unspecified; HMG-BOX DOMAINS is also available