Histone Deacetylases - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Epigenetic regulation of microRNA expression in colorectal cancer.

29 Nov 2009 In the last years, microRNAs (miRNA) have emerged as new molecular players involved in carcinogenesis. Deregulation of miRNAs expression has been shown in different human cancer but the molecular mechanism underlying the alteration of miRNA ... Read more...

Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola.

29 Sep 2009 Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC). A chemically unrelated HDAC inhibitor, HC toxin, was earlier shown to be a major virulence factor in ... Read more...

Antidepressant actions of histone deacetylase inhibitors.

14 Sep 2009 Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin remodeling. We find that chronic social defeat stress in mice causes a transient decrease, followed ... Read more...

Latest indexed articles for 'Histone Deacetylases - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Epigenetic regulation of microRNA expression in colorectal cancer. 29 Nov 2009
• Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola. 29 Sep 2009
• Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
• Epigenetic therapies move into new territory, but how exactly do they work? 13 Sep 2009
• Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker. 6 Sep 2009
• Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. 2 Sep 2009
• Real-time imaging of histone H4 hyperacetylation in living cells. Sep 2009
• KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2). 30 Aug 2009
• Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. 30 Aug 2009
• Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 30 Aug 2009
• Vorinostat for the treatment of bullous pemphigoid in the setting of advanced, refractory cutaneous T-cell lymphoma. 30 Aug 2009
• MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. 30 Aug 2009
• Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells. 30 Aug 2009
• Small molecule inhibitors in children with malignant gliomas. 30 Aug 2009
• Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. 23 Aug 2009
• Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. 23 Aug 2009
• Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. 19 Aug 2009
• Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. 18 Aug 2009
• Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. 13 Aug 2009
• Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). 13 Aug 2009

See a longer list of these articles.

Technical information about 'Histone Deacetylases'

Definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family.

Registry Number: EC 3.5.1.-

Descriptor UI: D006655

Alternative terms: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone;

Related Mesh Headings: Sirtuins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.087.520;

History Note: 2003; use AMIDOHYDROLASES 1975-1990

Technical Notes: if NAD-dependent histone deacetylase coord with SIRTUINS