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Histone Deacetylases - Deficiency
Research News and Information
Definition of 'Histone Deacetylases'Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family. Common names: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone |
Monday, November 23, 2009
19 Jul 2009 
We investigated the role of histone deacetylase 4 (HDAC4) using RNA interference (RNAi) and knockout cells to specifically address its role in cell cycle progression in tumor and normal cells. Ablation of HDAC4 led to growth inhibition in human ... Read more...
Histone H4 lysine 16 acetylation regulates cellular lifespan.
9 Jun 2009 Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a ... Read more...
HDAC2 negatively regulates memory formation and synaptic plasticity.
5 May 2009 Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and memory in wild-type mice as ... Read more...
Latest indexed articles for 'Histone Deacetylases - Deficiency'
These are the very latest articles for this heading:
- Histone modifier, the gatekeeper of good memory.
30 Jul 2009 - Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells. 19 Jul 2009
- Histone H4 lysine 16 acetylation regulates cellular lifespan. 9 Jun 2009
- HDAC2 negatively regulates memory formation and synaptic plasticity. 5 May 2009
- Polydactyly in mice lacking HDAC9/HDRP.
12 May 2008 - Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. 18 Mar 2008
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. 10 Mar 2008
- Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. 28 Feb 2008
- HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity. 17 Jan 2008
- Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. 5 Jan 2008
- Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. 15 Dec 2007
- Blocking HDACs boosts regulatory T cells. 30 Oct 2007
- Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. 29 Sep 2007
- Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. 30 Aug 2007
- Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. 7 Aug 2007
- Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae. 23 Jul 2007
- Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. 13 Jul 2007
- Role for histone deacetylase 1 in human tumor cell proliferation. 28 Apr 2007
- HDAC2 controls IgM H- and L-chain gene expressions via EBF1, Pax5, Ikaros, Aiolos and E2A gene expressions. 27 Feb 2007
- Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. 16 Feb 2007
See a longer list of these articles.
Technical information about 'Histone Deacetylases'
Definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family.
Registry Number: EC 3.5.1.-
Descriptor UI: D006655
Alternative terms: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone;
Related Mesh Headings: Sirtuins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;
Tree Number: D08.811.277.087.520;
History Note: 2003; use AMIDOHYDROLASES 1975-1990
Technical Notes: if NAD-dependent histone deacetylase coord with SIRTUINS