 |
Histone Deacetylases - Genetics
Research News and Information
Definition of 'Histone Deacetylases'Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family. Common names: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone |
Monday, November 23, 2009
10 Oct 2009 
Multifunctional adaptor protein APPL1 [adaptor protein containing PH (pleckstrin homology) domain, PTB (phosphotyrosine binding) domain and leucine zipper motif] belongs to a growing group of endocytic proteins which actively participate in various ... Read more...
7 Oct 2009 The vitamin D receptor (VDR) and its corepressor Hairless (HR) are thought to regulate key steps in the hair cycle because mutations in VDR or HR cause alopecia in humans and mice. Many mammalian cells express two major HR isoforms due to ... Read more...
29 Sep 2009 Hox proteins form complexes with Pbx and Meis cofactors to control gene expression, but the role of Meis is unclear. We demonstrate that Hoxb1-regulated promoters are highly acetylated on histone H4 (AcH4) and occupied by Hoxb1, Pbx, and Meis in ... Read more...
Latest indexed articles for 'Histone Deacetylases - Genetics'
These are the very latest articles for this heading:
- cDNA microarray expression profile in vestibular schwannoma: correlation with clinical and radiological features.
13 Oct 2009 - Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. 10 Oct 2009
- Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. 7 Oct 2009
- Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. 29 Sep 2009
- Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. 22 Sep 2009
- Reconstitution of heterochromatin-dependent transcriptional gene silencing. 22 Sep 2009
- Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
- Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2. 13 Sep 2009
- ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. 13 Sep 2009
- Ageing-related chromatin defects through loss of the NURD complex. 4 Sep 2009
- Phytochrome B and histone deacetylase 6 control light-induced chromatin compaction in Arabidopsis thaliana. 2 Sep 2009
- Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. 31 Aug 2009
- Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries. 23 Aug 2009
- Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. 18 Aug 2009
- Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. 11 Aug 2009
- Rice histone deacetylase genes display specific expression patterns and developmental functions. 3 Aug 2009
- Histone modifier, the gatekeeper of good memory. 30 Jul 2009
- Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter. 29 Jul 2009
- Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae. 26 Jul 2009
- Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation. 24 Jul 2009
See a longer list of these articles.
Technical information about 'Histone Deacetylases'
Definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family.
Registry Number: EC 3.5.1.-
Descriptor UI: D006655
Alternative terms: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone;
Related Mesh Headings: Sirtuins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;
Tree Number: D08.811.277.087.520;
History Note: 2003; use AMIDOHYDROLASES 1975-1990
Technical Notes: if NAD-dependent histone deacetylase coord with SIRTUINS