Histone Deacetylases
Research News and Information

Sunday, November 22, 2009

Epigenetic regulation of microRNA expression in colorectal cancer.

29 Nov 2009 In the last years, microRNAs (miRNA) have emerged as new molecular players involved in carcinogenesis. Deregulation of miRNAs expression has been shown in different human cancer but the molecular mechanism underlying the alteration of miRNA ... Read more...

Protein phosphatase 1 regulates the histone code for long-term memory.

12 Oct 2009 Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA methylation has recently been implicated in cognitive functions, but the mechanisms involved in such epigenetic regulation remain poorly understood. Here, we show ... Read more...

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.

10 Oct 2009 Multifunctional adaptor protein APPL1 [adaptor protein containing PH (pleckstrin homology) domain, PTB (phosphotyrosine binding) domain and leucine zipper motif] belongs to a growing group of endocytic proteins which actively participate in various ... Read more...

Latest indexed articles for 'Histone Deacetylases'

These are the very latest articles for this heading:

• Epigenetic regulation of microRNA expression in colorectal cancer. 29 Nov 2009
• cDNA microarray expression profile in vestibular schwannoma: correlation with clinical and radiological features. 13 Oct 2009
• Protein phosphatase 1 regulates the histone code for long-term memory. 12 Oct 2009
• Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. 10 Oct 2009
• Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. 7 Oct 2009
• NURD keeps chromatin young. 29 Sep 2009
• Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. 29 Sep 2009
• Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola. 29 Sep 2009
• E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. 22 Sep 2009
• Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. 22 Sep 2009
• Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. 22 Sep 2009
• Reconstitution of heterochromatin-dependent transcriptional gene silencing. 22 Sep 2009
• Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. 16 Sep 2009
• Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. 16 Sep 2009
• Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
• Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2. 13 Sep 2009
• Epigenetic therapies move into new territory, but how exactly do they work? 13 Sep 2009
• ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. 13 Sep 2009
• Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker. 6 Sep 2009
• Ageing-related chromatin defects through loss of the NURD complex. 4 Sep 2009

See a longer list of these articles.

Technical information about 'Histone Deacetylases'

Definition: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. Some of these belong to the SIRTUINS protein family.

Registry Number: EC 3.5.1.-

Descriptor UI: D006655

Alternative terms: Histone Deacetylases; Deacetylases, Histone; HDAC Proteins; Proteins, HDAC; Histone Deacetylase; Deacetylase, Histone;

Related Mesh Headings: Sirtuins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.087.520;

History Note: 2003; use AMIDOHYDROLASES 1975-1990

Technical Notes: if NAD-dependent histone deacetylase coord with SIRTUINS