HLA-B Antigens - Genetics
Research News and Information

Saturday, November 21, 2009

HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.

13 Oct 2009 OBJECTIVE: To quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers. METHODS: Relevant studies were identified using the ... Read more...

Duplications of the functional CYP21A2 gene are primarily restricted to Q318X alleles: evidence for a founder effect.

20 Sep 2009 CONTEXT: Rare haplotypes with Q318X mutations and duplicated CYP21A2 genes have been reported to occur in different populations to a varying extent. Discrimination between a normal (Q318X mutation on one of the duplicated CYP21A2 genes) and a ... Read more...

Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role of HLA allele products presenting conserved EBV epitopes.

13 Sep 2009 The role of genetic factors involved in the development of undifferentiated nasopharyngeal carcinoma (UNPC) in nonendemic areas has been poorly investigated. High-resolution human leukocyte antigen (HLA) class I genotyping carried out in 82 Italian ... Read more...

Latest indexed articles for 'HLA-B Antigens - Genetics'

These are the very latest articles for this heading:

• HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies. 13 Oct 2009
• Duplications of the functional CYP21A2 gene are primarily restricted to Q318X alleles: evidence for a founder effect. 20 Sep 2009
• Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role of HLA allele products presenting conserved EBV epitopes. 13 Sep 2009
• Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. 12 Sep 2009
• An approach to predicting hematopoietic stem cell transplantation outcome using HLA-mismatch information mapped on protein structure data. 30 Aug 2009
• Cognitive functioning in Behçet's disease. 30 Aug 2009
• Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. 30 Aug 2009
• Role of HLA class I (HLA-A, B) and HLA class II (HLA-DRB, DQB) in HIV-1 patients with and without pulmonary tuberculosis. 13 Aug 2009
• Multiple Loci within the major histocompatibility complex confer risk of psoriasis. 12 Aug 2009
• Preface. Drug hypersensitivity. 30 Jul 2009
• Foreword. Drug allergy and primum non-nocere. 30 Jul 2009
• A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy. 25 Jul 2009
• A new CYP21A1P/CYP21A2 chimeric gene identified in an Italian woman suffering from classical congenital adrenal hyperplasia form. 20 Jul 2009
• Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. 13 Jul 2009
• The convenience of flow cytometry for HLA-B*5701 screening to prevent abacavir hypersensitivity reactions. 29 Jun 2009
• KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors. 29 Jun 2009
• New testing approach in HLA genotyping helps overcome barriers in effective clinical practice. 23 Jun 2009
• Cellular immune response to cryptic epitopes during therapeutic gene transfer. 14 Jun 2009
• Renal after cardiothoracic transplant: the effect of repeat mismatches on outcome. 13 Jun 2009
• HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia. 9 Jun 2009

See a longer list of these articles.

Technical information about 'HLA-B Antigens'

Definition: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

Registry Number: 0

Descriptor UI: D015235

Alternative terms: HLA-B Antigens; HLA B Antigens; HLA-B; Antigens, HLA-B; Antigens, HLA B;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D23.050.301.500.400.380; D23.050.301.500.450.380; D23.050.705.552.400.380; D23.050.705.552.450.380;

History Note: 89

Technical Notes: assoc with predisposition to rheumatoid & other autoimmune disord; DF: HLA B