HLA-B Antigens - Metabolism
Research News and Information

Monday, November 23, 2009

Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402.

12 Sep 2009 Comparison of mutant killer cell Ig-like receptor (KIR) 3DL1*015 substituted at natural positions of variation showed that tryptophan/leucine dimorphism at position 283 uniquely changes receptor conformation and can strongly influence binding of the ... Read more...

Killer Ig-like receptor ligand mismatch directs NK cell expansion in vitro.

9 Sep 2009 NK cell alloreactivity is governed largely through failure to detect self-HLA class I ligands by the clonally distributed inhibitory killer Ig-like receptors (KIR) expressed on the NK cell surface. In this study, we investigated the extent to which ... Read more...

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.

13 Jul 2009 A broad Gag-specific CD8(+) T-cell response is associated with effective control of adult human immunodeficiency virus (HIV) infection. The association of certain HLA class I molecules, such as HLA-B*57, -B*5801, and -B*8101, with immune control is ... Read more...

Latest indexed articles for 'HLA-B Antigens - Metabolism'

These are the very latest articles for this heading:

• Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. 12 Sep 2009
• Killer Ig-like receptor ligand mismatch directs NK cell expansion in vitro. 9 Sep 2009
• Preface. Drug hypersensitivity. 30 Jul 2009
• Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection. 13 Jul 2009
• Cellular immune response to cryptic epitopes during therapeutic gene transfer. 14 Jun 2009
• Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. 30 May 2009
• Recombinant chymosin used for exact and complete removal of a prochymosin derived fusion tag releasing intact native target protein. 29 Apr 2009
• A comparative study of HLA binding affinity and ligand diversity: implications for generating immunodominant CD8+ T cell responses. 30 Jan 2009
• Identification and characterization of 2 HIV-1 Gag immunodominant epitopes restricted by Asian HLA allele HLA-B*4801. 20 Jan 2009
• The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length. 18 Jan 2009
• Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. 10 Jan 2009
• Presentation of cytosolically stable peptides by HLA-B27 is not dependent on the canonic interactions of N-terminal basic residues in the A pocket. 30 Dec 2008
• Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins. 29 Nov 2008
• Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling. 30 Oct 2008
• Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1. 30 Oct 2008
• KIR-HLA intercourse in HIV disease. 27 Oct 2008
• Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans. 24 Oct 2008
• Role of the inhibitory KIR ligand HLA-Bw4 and HLA-C expression levels in the recognition of leukemic cells by Natural Killer cells. 6 Oct 2008
• Despite biased TRBV gene usage against a dominant HLA B57-restricted epitope, TCR diversity can provide recognition of circulating epitope variants. 29 Sep 2008
• Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells. 27 Aug 2008

See a longer list of these articles.

Technical information about 'HLA-B Antigens'

Definition: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

Registry Number: 0

Descriptor UI: D015235

Alternative terms: HLA-B Antigens; HLA B Antigens; HLA-B; Antigens, HLA-B; Antigens, HLA B;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D23.050.301.500.400.380; D23.050.301.500.450.380; D23.050.705.552.400.380; D23.050.705.552.450.380;

History Note: 89

Technical Notes: assoc with predisposition to rheumatoid & other autoimmune disord; DF: HLA B