HLA-DR Antigens - Research News and Information

Saturday, January 10, 2009

The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation.

13 Oct 2008 Human plasmacytoid dendritic cells (PDCs) can drive naive, allogeneic CD4(+)CD25(-) T cells to differentiate into CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). However, the intracellular mechanism or mechanisms underlying PDC-induced Treg ... Read more...

Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery.

13 Oct 2008 Myelin basic protein (MBP)-specific T cells are thought to play a role in the development of multiple sclerosis. MBP residues 111-129 compose an immunodominant epitope cluster restricted by HLA-DRB1*0401. The sequence of residues 111-129 of MBP ... Read more...

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.

13 Oct 2008 Genetic susceptibility to multiple sclerosis (MS) is associated with the MHC located on chromosome 6p21. This signal maps primarily to a 1-Mb region encompassing the HLA class II loci, and it segregates often with the HLA-DQB1*0602, -DQA1*0102, ... Read more...

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Latest indexed articles for 'HLA-DR Antigens'

These are the very latest articles for this heading:

• Re: HLA-DRB1 and multiple sclerosis in Malta. 19 Oct 2008
• The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. 13 Oct 2008
• Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery. 13 Oct 2008
• Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. 13 Oct 2008
• Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. 13 Oct 2008
• Longitudinal observation of parechovirus in stool samples from Norwegian infants. 29 Sep 2008
• Pancreas histology and a longitudinal study of insulin secretion in a Japanese patient with latent autoimmune diabetes in adults. 29 Sep 2008
• Human leukocyte antigen-ABDR genes in pulmonary adenocarcinoma cell lines. 29 Sep 2008
• Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. 29 Sep 2008
• Genetic alterations of HLA-class II in ovarian cancer. 13 Sep 2008
• Human leukocyte antigen class II antibodies and transplant outcome. 13 Sep 2008
• Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. 6 Sep 2008
• HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility. 31 Aug 2008
• Genetics of sarcoidosis. 30 Aug 2008
• Diagnosis of sarcoidosis. 30 Aug 2008
• Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice. 30 Aug 2008
• Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. 30 Aug 2008
• Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. 30 Aug 2008
• Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes. 30 Aug 2008
• Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with chronic allograft nephropathy and graft survival in Korean renal transplant recipients. 30 Aug 2008

See a longer list of these articles.

Technical information about 'HLA-DR Antigens'

Definition: A group of D-related human leukocyte antigens that are polymorphic glycoproteins found on lymphoid cells. They consist of alpha and beta chains and their inheritance differs from that of the DQ and DP antigens; their presence seems to be associated with certain skin diseases like pemphigus vulgaris, dermatitis herpetiformis, and type I diabetes.

Registry Number: 0

Descriptor UI: D006684

Alternative terms: HLA-DR Antigens; Antigens, HLA-DR; HLA DR Antigens; HLA-BR; HLA-BR Antigens; Antigens, HLA-BR; HLA BR Antigens; HLA-MT Antigens; Antigens, HLA-MT; HLA MT Antigens; HLA-MT; HLA-D-Related Antigens; Antigens, HLA-D-Related; HLA D Related Antigens; HLA-DR; HLA-DR alpha; HLA DR alpha; HLA-DR beta; HLA DR beta;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D23.050.301.500.410.400.440; D23.050.301.500.450.400.440; D23.050.705.552.410.400.440; D23.050.705.552.450.400.440;

History Note: 89(87); was see under HLA-D ANTIGENS 1987-88

Technical Notes: GEN: prefer specifics; assoc with various skin dis & insulin-depend diabetes mellitus; DF: HLA DR