Homeodomain Proteins - Antagonists & inhibitors
Research News and Information

Sunday, November 22, 2009

Six2 activity is required for the formation of the mammalian pyloric sphincter.

Aug 2009 The functional activity of Six2, a member of the so/Six family of homeodomain-containing transcription factors, is required during mammalian kidney organogenesis. We have now determined that Six2 activity is also necessary for the formation of the ... Read more...

Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate.

Aug 2009 A transition metal complex targeted for the inhibition of a subset of zinc finger transcription factors has been synthesized and tested in Xenopus laevis. A Co(III) Schiff base complex modified with a 17-bp DNA sequence is designed to selectively ... Read more...

Emx3 is required for the differentiation of dorsal telencephalic neurons.

30 Jul 2009 emx3 is first expressed in prospective telencephalic cells at the anterior border of the zebrafish neural plate. Knockdown of Emx3 function by morpholino reduces the expression of markers specific to dorsal telencephalon, and impairs axon tract ... Read more...

Latest indexed articles for 'Homeodomain Proteins - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Six2 activity is required for the formation of the mammalian pyloric sphincter. Aug 2009
• Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Aug 2009
• Emx3 is required for the differentiation of dorsal telencephalic neurons. 30 Jul 2009
• Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories. Jun 2009
• Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. 30 May 2009
• Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. 12 May 2009
• Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Apr 2009
• BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. 30 Mar 2009
• CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. 23 Mar 2009
• Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. 2 Dec 2008
• HOXA9 is required for survival in human MLL-rearranged acute leukemias. Dec 2008
• Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling. 29 Nov 2008
• Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. 30 Oct 2008
• Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism. 3 Oct 2008
• Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. 29 Sep 2008
• Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. 16 Sep 2008
• Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. 30 Aug 2008
• A dual requirement for Iroquois genes during Xenopus kidney development. 18 Aug 2008
• PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer. 30 Jul 2008
• Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping. 7 Jul 2008

See a longer list of these articles.

Technical information about 'Homeodomain Proteins'

Definition: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

Registry Number: 0

Descriptor UI: D018398

Alternative terms: Homeodomain Proteins; Proteins, Homeodomain; Homeobox Proteins; Proteins, Homeobox; Homeotic Proteins; Proteins, Homeotic; Homeoproteins; Homeo Domain Proteins; Proteins, Homeo Domain;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.400;

History Note: 95

Technical Notes: DNA-binding proteins