Homeodomain Proteins - Genetics
Research News and Information

Saturday, November 21, 2009

Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcoma.

30 Oct 2009 Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and rarely occurs in adults. There are six main subtypes, each histologically, clinically, and cytogenetically distinct. Embryonal RMS is characterized by chromosomal gains, ... Read more...

Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event.

30 Oct 2009 Pediatric undifferentiated soft tissue sarcomas (USTS) are a diagnostically challenging group of neoplasms. Recently, a subcategory of USTS with primitive round cell morphology and a t(4;19)(q35;q13) rearrangement has been defined. The present study ... Read more...

In vitro propagation and characterization of neoplastic stem/progenitor-like cells from human prostate cancer tissue.

30 Oct 2009 BACKGROUND: According to the cancer stem cell hypothesis, tumor growth is sustained by a subpopulation of cancer stem/progenitor-like cells. Self-renewal and high clonogenic potential are characteristics shared by normal stem and neoplastic ... Read more...

Latest indexed articles for 'Homeodomain Proteins - Genetics'

These are the very latest articles for this heading:

• Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcoma. 30 Oct 2009
• Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event. 30 Oct 2009
• In vitro propagation and characterization of neoplastic stem/progenitor-like cells from human prostate cancer tissue. 30 Oct 2009
• HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. 30 Oct 2009
• Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. 13 Oct 2009
• Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. 12 Oct 2009
• A lymphotoxin-driven pathway to hepatocellular carcinoma. 4 Oct 2009
• Retinal input instructs alignment of visual topographic maps. 30 Sep 2009
• Addressing Alzheimer's disease tangles: from NAP to AL-108. 29 Sep 2009
• NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism. 29 Sep 2009
• IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. 29 Sep 2009
• Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. 29 Sep 2009
• Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 29 Sep 2009
• More than patterning--Hox genes and the control of posterior axial elongation. 29 Sep 2009
• Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration. 29 Sep 2009
• Regulation of CDX2 expression in esophageal adenocarcinoma. 29 Sep 2009
• Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. 29 Sep 2009
• Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. 29 Sep 2009
• The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction. 29 Sep 2009
• CDX2 promoter methylation is not associated with mRNA expression. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Homeodomain Proteins'

Definition: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

Registry Number: 0

Descriptor UI: D018398

Alternative terms: Homeodomain Proteins; Proteins, Homeodomain; Homeobox Proteins; Proteins, Homeobox; Homeotic Proteins; Proteins, Homeotic; Homeoproteins; Homeo Domain Proteins; Proteins, Homeo Domain;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.400;

History Note: 95

Technical Notes: DNA-binding proteins