Hydroxamic Acids - Pharmacology
Research News and Information

Monday, November 23, 2009

Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.

6 Oct 2009 Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA ... Read more...

Real-time imaging of histone H4 hyperacetylation in living cells.

Sep 2009 To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer (FRET)-based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. ... Read more...

Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma.

30 Aug 2009 The ability of HIV to establish a latent infection causes life-long virus persistence, even after long-term highly active antiretroviral therapy (HAART). The role that latency is playing in preventing clearance of the virus infection has become ... Read more...

Latest indexed articles for 'Hydroxamic Acids - Pharmacology'

These are the very latest articles for this heading:

• Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. 6 Oct 2009
• Real-time imaging of histone H4 hyperacetylation in living cells. Sep 2009
• Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma. 30 Aug 2009
• KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2). 30 Aug 2009
• Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. 30 Aug 2009
• Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 30 Aug 2009
• MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. 30 Aug 2009
• Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. 30 Aug 2009
• Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. 30 Aug 2009
• Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. 23 Aug 2009
• Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. 19 Aug 2009
• Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. 13 Aug 2009
• Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). 13 Aug 2009
• Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. 12 Aug 2009
• N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. 11 Aug 2009
• MeCP2 function in the basolateral amygdala in Rett syndrome. 10 Aug 2009
• Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. 6 Aug 2009
• Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups. 30 Jul 2009
• Histone modifier, the gatekeeper of good memory. 30 Jul 2009
• The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Hydroxamic Acids'

Definition: A class of weak acids with the general formula R-CONHOH.

Registry Number: 0

Descriptor UI: D006877

Alternative terms: Hydroxamic Acids; Acids, Hydroxamic; Hydroxamic Acid; Acid, Hydroxamic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.092.570.394; D02.241.511.372;

Online Note: use HYDROXAMIC ACIDS to search HYDROXAMIC ACID 1966-74

History Note: 75; was HYDROXAMIC ACID 1963-74