Hyperalgesia - Chemically induced
Research News and Information

Tuesday, November 24, 2009

Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.

19 Oct 2009 Peripheral tissue injury is associated with changes in protein expression in sensory neurons that may contribute to abnormal nociceptive processing. We used cultured dorsal root ganglion (DRG) neurons as a model of axotomized neurons to investigate ... Read more...

Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans.

26 Aug 2009 BACKGROUND: Although magnesium ions (Mg2+) are known to display many similar features to other 2+ charged cations, they seem to have quite an important and unique role in biological settings, such as NMDA blocking effect. However, the role of Mg2+ ... Read more...

The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome.

4 Aug 2009 BACKGROUND: The pathogenesis of visceral hypersensitivity, a characteristic pathophysiological feature of irritable bowel syndrome (IBS), remains elusive. Recent studies suggest a role for hydrogen sulfide (H2S) in pain signaling but this has not ... Read more...

Latest indexed articles for 'Hyperalgesia - Chemically induced'

These are the very latest articles for this heading:

• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans. 26 Aug 2009
• The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome. 4 Aug 2009
• Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. 30 Jul 2009
• Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. 25 Jul 2009
• Induction of synaptic long-term potentiation after opioid withdrawal. 8 Jul 2009
• Do opioids induce hyperalgesia in humans? An evidence-based structured review. 4 Jul 2009
• Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65. 29 Jun 2009
• Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice. 29 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice. 19 Jun 2009
• Mustard oil enhances spinal neuronal responses to noxious heat but not cooling. 19 Jun 2009
• Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions. 11 Jun 2009
• Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain. 9 Jun 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Oxaliplatin-induced painful neuropathy--flicker of hope or hopeless pain? 21 May 2009
• Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study. 17 May 2009
• TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. 11 May 2009
• The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. 5 May 2009

See a longer list of these articles.

Technical information about 'Hyperalgesia'

Definition: An increased sensation to painful stimuli that may follow damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia can occur both at the site of tissue damage (primary hyperalgesia) and in the surrounding undamaged areas (secondary hyperalgesia). (Kandel et al., Principles of Neural Science, 3d ed, p386)

Descriptor UI: D006930

Alternative terms: Hyperalgesia; Hyperalgesias; Hyperalgesic Sensations; Hyperalgesic Sensation; Sensation, Hyperalgesic; Sensations, Hyperalgesic; Hyperalgesia, Secondary; Hyperalgesias, Secondary; Secondary Hyperalgesia; Secondary Hyperalgesias; Hyperalgesia, Thermal; Hyperalgesias, Thermal; Thermal Hyperalgesia; Thermal Hyperalgesias; Hyperalgesia, Primary; Hyperalgesias, Primary; Primary Hyperalgesia; Primary Hyperalgesias; Hyperalgesia, Tactile; Hyperalgesias, Tactile; Tactile Hyperalgesia; Tactile Hyperalgesias;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.597.751.791.400; C23.888.592.763.770.400;

History Note: 1991(1975)

Technical Notes: coord with TOUCH or HOT TEMPERATURE if pertinent