Hyperalgesia
Research News and Information

Sunday, November 22, 2009

Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.

19 Oct 2009 Peripheral tissue injury is associated with changes in protein expression in sensory neurons that may contribute to abnormal nociceptive processing. We used cultured dorsal root ganglion (DRG) neurons as a model of axotomized neurons to investigate ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

19 Oct 2009 Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological ... Read more...

Latest indexed articles for 'Hyperalgesia'

These are the very latest articles for this heading:

• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. 19 Oct 2009
• Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats. 12 Oct 2009
• Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. 29 Sep 2009
• The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. 29 Sep 2009
• Complete Freund's adjuvant-induced intervertebral discitis as an animal model for discogenic low back pain. 29 Sep 2009
• 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. 22 Sep 2009
• Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). 22 Sep 2009
• Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. 21 Sep 2009
• Medial prefrontal cortex, secondary hyperalgesia, and the default mode network. 14 Sep 2009
• Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. 2 Sep 2009
• Central sensitization: a generator of pain hypersensitivity by central neural plasticity. 30 Aug 2009
• Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats. 30 Aug 2009
• Both happy and sad melodies modulate tonic human heat pain. 30 Aug 2009
• Quantitative sensory testing and mapping: a review of nonautomated quantitative methods for examination of the patient with neuropathic pain. 30 Aug 2009
• Widespread mechanical pain hypersensitivity as sign of central sensitization in unilateral epicondylalgia: a blinded, controlled study. 30 Aug 2009
• Central post-stroke pain: clinical characteristics, pathophysiology, and management. 30 Aug 2009
• Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model. 30 Aug 2009
• A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Hyperalgesia'

Definition: An increased sensation to painful stimuli that may follow damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia can occur both at the site of tissue damage (primary hyperalgesia) and in the surrounding undamaged areas (secondary hyperalgesia). (Kandel et al., Principles of Neural Science, 3d ed, p386)

Descriptor UI: D006930

Alternative terms: Hyperalgesia; Hyperalgesias; Hyperalgesic Sensations; Hyperalgesic Sensation; Sensation, Hyperalgesic; Sensations, Hyperalgesic; Hyperalgesia, Secondary; Hyperalgesias, Secondary; Secondary Hyperalgesia; Secondary Hyperalgesias; Hyperalgesia, Thermal; Hyperalgesias, Thermal; Thermal Hyperalgesia; Thermal Hyperalgesias; Hyperalgesia, Primary; Hyperalgesias, Primary; Primary Hyperalgesia; Primary Hyperalgesias; Hyperalgesia, Tactile; Hyperalgesias, Tactile; Tactile Hyperalgesia; Tactile Hyperalgesias;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C10.597.751.791.400; C23.888.592.763.770.400;

History Note: 1991(1975)

Technical Notes: coord with TOUCH or HOT TEMPERATURE if pertinent