Hypnotics and Sedatives - Pharmacokinetics
Research News and Information

Monday, November 23, 2009

Low-dose oral midazolam reduces fear and distress during needle procedures in children with cancer.

13 Dec 2009 BACKGROUND: Children with cancer often mention needle procedures as the most frightening, distressing, and sometimes painful aspect of the disease and treatment. The aim was to investigate whether children experience less fear, distress, and/or pain ... Read more...

When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration.

30 Oct 2009 Twenty-three hours after heart transplantation, life-threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants ... Read more...

Short half-life hypnotics preserve physical fitness and altitude tolerance during military mountainous training.

30 Aug 2009 OBJECTIVE: We study the effect of short half-life hypnotics (zaleplon or zolpidem against placebo) on altitude tolerance in 12 nonacclimated male soldiers (age, 22.1 +/- 0.8 years; height, 177.8 +/- 1.7 cm; weight, 69.8 +/- 1.7 kg). METHODS: ... Read more...

Latest indexed articles for 'Hypnotics and Sedatives - Pharmacokinetics'

These are the very latest articles for this heading:

• Low-dose oral midazolam reduces fear and distress during needle procedures in children with cancer. 13 Dec 2009
• When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration. 30 Oct 2009
• Short half-life hypnotics preserve physical fitness and altitude tolerance during military mountainous training. 30 Aug 2009
• [Agomelatine] 30 Jul 2009
• Sedation after intubation using etomidate and a long-acting neuromuscular blocker. 30 May 2009
• Novel zolpidem formulations. 29 Apr 2009
• Is propofol the perfect hypnotic agent for procedural sedation in neonates? 29 Apr 2009
• Effects of statins on the pharmacokinetics of midazolam in healthy volunteers. 29 Apr 2009
• Mixed-effects modeling of the influence of midazolam on propofol pharmacokinetics. 29 Apr 2009
• Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses. 30 Mar 2009
• Fatigue countermeasures and the use of hypnotics in aircrew. 30 Mar 2009
• Effects of midazolam on brain injury after transient focal cerebral ischemia in rats*. 30 Mar 2009
• [Management of transdermal therapeutics in perioperative care] 19 Mar 2009
• Closed-loop control for intensive care unit sedation. 27 Feb 2009
• Manual versus target-controlled infusion remifentanil administration in spontaneously breathing patients. 27 Feb 2009
• Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem. 23 Feb 2009
• [Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam] 30 Jan 2009
• Impact of time-dependent inactivation on the estimation of enzyme kinetic parameters for midazolam. 30 Dec 2008
• In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry. 30 Dec 2008
• The use of a clinical utility index to compare insomnia compounds: a quantitative basis for benefit-risk assessment. 8 Dec 2008

See a longer list of these articles.

Technical information about 'Hypnotics and Sedatives'

Definition: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.

Registry Number: 0

Descriptor UI: D006993

Alternative terms: Hypnotics and Sedatives; Sedatives and Hypnotics; Sedatives; Hypnotics;

Related Mesh Headings: Histamine H1 Antagonists; Tranquilizing Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.277.350; D27.505.696.410; D27.505.954.427.210.350; D27.505.954.427.325;

Technical Notes: CNS depressants; GEN: prefer specifics; DF: HYPNOTICS