Hypoglycemic Agents - Toxicity
Research News and Information

Sunday, November 22, 2009

Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.

7 Jun 2009 OBJECTIVE: Clinical reports link use of the glucagon-like peptide-1 receptor (GLP-1R) agonists exenatide and liraglutide to pancreatitis. However, whether these agents act on the exocrine pancreas is poorly understood. RESEARCH DESIGN AND METHODS: ... Read more...

PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.

25 May 2009 Peroxisome proliferator-activated receptor (PPAR) gamma is known to be a key regulator of insulin resistance. PAR-1622 is a novel small molecule compound synthesized in Dong-A research center. In this study, we characterized the pharmacological ... Read more...

Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.

7 May 2009 ETHNOPHARMACOLOGICAL RELEVANCE: The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. AIM OF THE STUDY: To identify the compounds responsible for blood glucose ... Read more...

Latest indexed articles for 'Hypoglycemic Agents - Toxicity'

These are the very latest articles for this heading:

• Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice. 7 Jun 2009
• PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention. 25 May 2009
• Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. 7 May 2009
• Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes. 3 May 2009
• Rosiglitazone is associated with mortality in chronic hemodialysis patients. 6 Apr 2009
• Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet. 30 Mar 2009
• Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people. 29 Mar 2009
• Effects of once-daily sitagliptin on 24-h glucose control following 4 weeks of treatment in Japanese patients with type 2 diabetes mellitus. 25 Feb 2009
• Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. 30 Jan 2009
• The endocannabinoid system: a promising target for the management of type 2 diabetes. 30 Jan 2009
• Mitogenic potency of insulin glargine. 30 Dec 2008
• Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Dec 2008
• Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. 29 Nov 2008
• Severe hypoglycemia associated with an illegal sexual enhancement product adulterated with glibenclamide: MR imaging findings. 16 Nov 2008
• Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. 29 Oct 2008
• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. 8 Sep 2008
• Antihyperglycemic effect of Fomitopsis pinicola extracts in streptozotocin-induced diabetic rats. 30 Aug 2008
• Corticosterone release in oxytocin gene deletion mice following exposure to psychogenic versus non-psychogenic stress. 4 Jul 2008
• Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction. 9 Jun 2008
• Antidiabetic screening and scoring of 11 plants traditionally used in South Africa. 3 Jun 2008

See a longer list of these articles.

Technical information about 'Hypoglycemic Agents'

Definition: Agents which lower the blood glucose level.

Registry Number: 0

Descriptor UI: D007004

Alternative terms: Hypoglycemic Agents; Agents, Hypoglycemic; Hypoglycemics; Hypoglycemic Drugs; Drugs, Hypoglycemic; Antidiabetics; Antidiabetic Drugs; Drugs, Antidiabetic; Antidiabetic Agents; Agents, Antidiabetic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.422;

Online Note: use HYPOGLYCEMIC AGENTS to search ANTIDIABETICS 1966-75

History Note: 76; was NON MESH 1975, was see under ANTIDIABETICS 1968-74; ANTIDIABETICS was heading 1963-75