Ibotenic Acid - Pharmacology
Research News and Information

Sunday, November 22, 2009

The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions.

23 Jun 2009 The neural circuits for unconditioned fear to predator odors (e.g., cat fur odor, trimethylthiazoline, TMT) are not well delineated. A putative neural circuit for predator odor fear, the medial hypothalamic defensive circuit (MHDC), consisting of ... Read more...

The anteromedial extrastriate complex is critical for the use of allocentric visual cues and in the retention of the Lashley III maze task in rats.

14 Jun 2009 The anteromedial extrastriate complex has been proposed to play an essential role in a spatial orientation system in rats. To gain more information about that possible role, in the present work, two questions were addressed: 1. Are allocentric ... Read more...

The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory.

Jun 2009 The central nucleus of the amygdala (CeA) has been traditionally viewed in fear conditioning to serve as an output neural center that transfers conditioned information formed in the basolateral amygdala to brain structures that generate emotional ... Read more...

Latest indexed articles for 'Ibotenic Acid - Pharmacology'

These are the very latest articles for this heading:

• The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions. 23 Jun 2009
• The anteromedial extrastriate complex is critical for the use of allocentric visual cues and in the retention of the Lashley III maze task in rats. 14 Jun 2009
• The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. Jun 2009
• C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons. 25 Aug 2008
• Selective contributions of the medial preoptic nucleus to testosterone-dependant regulation of the paraventricular nucleus of the hypothalamus and the HPA axis. 4 Aug 2008
• Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour. 29 Jun 2008
• Hyperventilation evoked by activation of the vicinity of the caudal inferior olivary nucleus depends on the fastigial nucleus in anesthetized rats. 18 Mar 2008
• A functional dissociation of the anterior and posterior pedunculopontine tegmental nucleus: excitotoxic lesions have differential effects on locomotion and the response to nicotine. 10 Feb 2008
• Roles of dorsal column pathway and transient receptor potential vanilloid type 1 in augmentation of cerebral blood flow by upper cervical spinal cord stimulation in rats. 10 Jan 2008
• Raphe magnus nucleus is involved in ventilatory but not hypothermic response to CO2. 4 Sep 2007
• Difficulty overcoming learned non-reward during reversal learning in rats with ibotenic acid lesions of orbital prefrontal cortex. 12 Aug 2007
• Role of the primate amygdala in fear-potentiated startle: effects of chronic lesions in the rhesus monkey. 9 Jul 2007
• Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge. 26 Jun 2007
• Role of caspase-12 in amyloid beta-peptide-induced toxicity in organotypic hippocampal slices cultured for long periods. 22 Apr 2007
• Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors. Mar 2007
• Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid. 5 Feb 2007
• The cerebellar fastigial nucleus contributes to CO2-H+ ventilatory sensitivity in awake goats. 4 Feb 2007
• Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice. 10 Dec 2006
• Unilateral ibotenic acid lesions of the prefrontal cortex reduce rotational behavior in 6-hydroxydopamine-lesioned rats. 29 Nov 2006
• Ibotenic acid lesions reduce noradrenergic activation in ventromedial hypothalamus during hypoglycemia. 12 Aug 2006

See a longer list of these articles.

Technical information about 'Ibotenic Acid'

Definition: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.

Chemical name: 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-

Registry Number: 2552-55-8

Descriptor UI: D007051

Alternative terms: Ibotenic Acid; Acid, Ibotenic;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D03.383.129.385.231; D23.946.587.475;

History Note: 91(76); was see under OXAZOLES 1976-90