Ibotenic Acid - Toxicity
Research News and Information

Sunday, November 22, 2009

Lesions of the medial preoptic area interfere with the display of a conditioned place preference for vaginocervical stimulation in rats.

30 Jul 2009 The present study examined the effect of ibotenic acid lesions of the medial preoptic area (mPOA) on the expression of a conditioned place preference (CPP) for vaginocervical stimulation. Rats with bilateral lesions of the mPOA failed to display the ... Read more...

Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.

13 Jul 2009 The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats ... Read more...

Disruption of neuroendocrine stress responses to acute ferret odor by medial, but not central amygdala lesions in rats.

13 Jul 2009 Investigations of the neural pathways associated with responses to predators have implicated the medial amygdala (MeA) as an important region involved in defensive behaviors. To our knowledge, however, the involvement of the MeA in neuroendocrine ... Read more...

Latest indexed articles for 'Ibotenic Acid - Toxicity'

These are the very latest articles for this heading:

• Lesions of the medial preoptic area interfere with the display of a conditioned place preference for vaginocervical stimulation in rats. 30 Jul 2009
• Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. 13 Jul 2009
• Disruption of neuroendocrine stress responses to acute ferret odor by medial, but not central amygdala lesions in rats. 13 Jul 2009
• The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex. 22 Jun 2009
• Functional differentiation and cooperation among the hippocampal subregions in rats to effect spatial memory processes. 6 Jun 2009
• A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. Jun 2009
• Mediodorsal thalamic lesions block the stress-induced inversion of serial memory retrieval pattern in mice. 19 May 2009
• Chronic corticosterone treatment impairs trace conditioning in rats with a neonatal medial prefrontal cortex lesion. May 2009
• Neonatal ventral hippocampal lesions in male and female rats: effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood. 9 Apr 2009
• [Neurobehavioral function of neonatal mice following excitotoxic brain damage] 27 Feb 2009
• Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. 27 Feb 2009
• Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus. 30 Jan 2009
• [Economical body platform for neonatal rats stereotaxic surgery] 30 Jan 2009
• Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury. 29 Sep 2008
• The nonhuman primate amygdala is necessary for the acquisition but not the retention of fear-potentiated startle. 25 Sep 2008
• The neuronal activity of thalamic parafascicular nucleus is conversely regulated by nigrostriatal pathway and pedunculopontine nucleus in the rat. 14 Sep 2008
• Role of the median preoptic nucleus in chronic angiotensin II-induced hypertension. 14 Aug 2008
• Thalamic pathology in sudden cardiac death in epilepsy: a shed light on mysterious event. 7 Aug 2008
• Prefrontal control of trace eyeblink conditioning in rabbits: role in retrieval of the CR? 30 Jul 2008
• Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus. 22 May 2008

See a longer list of these articles.

Technical information about 'Ibotenic Acid'

Definition: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.

Chemical name: 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-

Registry Number: 2552-55-8

Descriptor UI: D007051

Alternative terms: Ibotenic Acid; Acid, Ibotenic;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D03.383.129.385.231; D23.946.587.475;

History Note: 91(76); was see under OXAZOLES 1976-90