Ibotenic Acid - Research News and Information

Saturday, January 10, 2009

Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury.

29 Sep 2008 Intracerebral injection of ibotenate in newborn rodents produces brain damage that mimics that of infants with cerebral palsy. Because maternal infection may contribute to brain injury in preterm infants, we investigated brain damage after maternal ... Read more...

Prefrontal control of trace eyeblink conditioning in rabbits: role in retrieval of the CR?

30 Jul 2008 Rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink (EB) conditioning task to a criterion of 10 consecutive EB conditioned responses (CRs). One week later, ibotenic acid or sham lesions were made in the mPFC centered on the prelimbic ... Read more...

Expression of Fos during sham sucrose intake in rats with central gustatory lesions.

14 Jul 2008 For humans and rodents, ingesting sucrose is rewarding. This experiment tested the prediction that the neural activity produced by sapid sucrose reaches reward systems via projections from the pons through the limbic system. Gastric cannulas ... Read more...

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Latest indexed articles for 'Ibotenic Acid'

These are the very latest articles for this heading:

• Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury. 29 Sep 2008
• Prefrontal control of trace eyeblink conditioning in rabbits: role in retrieval of the CR? 30 Jul 2008
• Expression of Fos during sham sucrose intake in rats with central gustatory lesions. 14 Jul 2008
• Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour. 29 Jun 2008
• Prefrontal cortex or basolateral amygdala lesions blocked the stress-induced inversion of serial memory retrieval pattern in mice. 22 Jun 2008
• Specific role of the posterior dorsal hippocampus-prefrontal cortex in short-term working memory. 4 Jun 2008
• Unexpected awakening from anaesthesia after hyperstimulation of the medial thalamus in the rat. 30 May 2008
• Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus. 22 May 2008
• Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats. 17 May 2008
• A neurochemical signature of visual recovery after extrastriate cortical damage in the adult cat. 29 Apr 2008
• Time-course of GDNF and its receptor expression after brain injury in the rat. 29 Apr 2008
• Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice. 23 Apr 2008
• Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity. 6 Apr 2008
• The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stress. 31 Mar 2008
• Hyperventilation evoked by activation of the vicinity of the caudal inferior olivary nucleus depends on the fastigial nucleus in anesthetized rats. 18 Mar 2008
• Neonatal lesions of the entorhinal cortex induce long-term changes of limbic brain regions and maze learning deficits in adult rats. 17 Mar 2008
• Glial alterations in the hippocampus of rats submitted to ibotenic-induced lesion of the nucleus basalis magnocellularis. 4 Mar 2008
• Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain. 11 Feb 2008
• A comparison of behavioural and histological outcomes of periventricular injection of ibotenic acid in neonatal rats at postnatal days 5 and 7. 4 Feb 2008
• Dorsal hippocampus, CA3, and CA1 lesions disrupt temporal sequence completion. 30 Jan 2008

See a longer list of these articles.

Technical information about 'Ibotenic Acid'

Definition: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.

Chemical name: 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-

Registry Number: 2552-55-8

Descriptor UI: D007051

Alternative terms: Ibotenic Acid; Acid, Ibotenic;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Excitatory Amino Acid Agonists;

Tree Number: D03.383.129.385.231; D23.946.587.475;

History Note: 91(76); was see under OXAZOLES 1976-90