Imidazoles - Research News and Information

Saturday, January 10, 2009

15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.

30 Oct 2008 We previously demonstrated that, in the MC615 cartilage cell line, the p38/NF-kB pathway is activated both during differentiation and in response to an inflammatory stimulus. In both cases, the p38/NF-kB pathway activation leads to the expression ... Read more...

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.

17 Oct 2008 Cardiac dysfunction following acute myocardial infarction is a major cause of death in the world and there is a compelling need for new therapeutic strategies. In this report we demonstrate that a direct cardiac injection of drug-loaded ... Read more...

Imidazoquinoline acts as immune adjuvant for functional alteration of thymic stromal lymphopoietin-mediated allergic T cell response.

13 Oct 2008 Atopic dermatitis is a major allergic disease that develops through dysregulation of Th2-mediated inflammation. Although dendritic cells (DCs) have been thought to play a critical role in the upstream phase of the allergic cascade, conventional ... Read more...

Learn Faster Today      Improve your study skills

Latest indexed articles for 'Imidazoles'

These are the very latest articles for this heading:

• 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. 30 Oct 2008
• Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction. 17 Oct 2008
• Imidazoquinoline acts as immune adjuvant for functional alteration of thymic stromal lymphopoietin-mediated allergic T cell response. 13 Oct 2008
• Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells. 13 Oct 2008
• Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. 13 Oct 2008
• Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels. 29 Sep 2008
• Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. 29 Sep 2008
• TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells. 29 Sep 2008
• Selective HOESY experiments for stereochemical determinations. 29 Sep 2008
• A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. 29 Sep 2008
• Ammonia impairs neutrophil phagocytic function in liver disease. 29 Sep 2008
• Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor. 29 Sep 2008
• Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine. 29 Sep 2008
• The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. 29 Sep 2008
• Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study. 29 Sep 2008
• Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite. 29 Sep 2008
• Local application of zoledronic acid incorporated in a poly(D,L-lactide)-coated implant accelerates fracture healing in rats. 29 Sep 2008
• Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles. 23 Sep 2008
• Zoledronic acid infusion and orbital inflammatory disease. 23 Sep 2008
• X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. 16 Sep 2008

See a longer list of these articles.

Technical information about 'Imidazoles'

Definition: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

Registry Number: 0

Descriptor UI: D007093

Alternative terms: Imidazoles;

Related Mesh Headings: Benzimidazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.129.308;