Immediate-Early Proteins - Metabolism
Research News and Information

Sunday, November 22, 2009

Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1.

23 Sep 2009 The role of SGK1 (serum- and glucocorticoid-induced protein kinase 1) in the glucocorticoid induction of alpha-ENaC (epithelial Na+ channel alpha subunit) gene transcription was explored by monitoring the transcriptional activity of a ... Read more...

Myosin II is required for interkinetic nuclear migration of neural progenitors.

7 Sep 2009 Interkinetic nuclear migration (INM) is a hallmark of the polarized stem and progenitor cells in the ventricular zone (VZ) of the developing vertebrate CNS. INM is responsible for the pseudostratification of the VZ, a crucial aspect of brain ... Read more...

Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels.

16 Aug 2009 WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuated by SGK1 (serum-glucocorticoids-induced kinase)-mediated phosphorylation. It has been suggested ... Read more...

Latest indexed articles for 'Immediate-Early Proteins - Metabolism'

These are the very latest articles for this heading:

• Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1. 23 Sep 2009
• Myosin II is required for interkinetic nuclear migration of neural progenitors. 7 Sep 2009
• Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels. 16 Aug 2009
• Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. 15 Aug 2009
• ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells. 10 Aug 2009
• Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p. 3 Aug 2009
• Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus. 3 Aug 2009
• Analysis of human cytomegalovirus-encoded microRNA activity during infection. 3 Aug 2009
• Pioglitazone induced gastric acid secretion. Aug 2009
• Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication. 21 Jul 2009
• Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway. 15 Jul 2009
• Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. 15 Jul 2009
• DUBs at a glance. 13 Jul 2009
• Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. 12 Jul 2009
• Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. 12 Jul 2009
• Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis. 6 Jul 2009
• Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. 6 Jul 2009
• Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. 5 Jul 2009
• Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. 29 Jun 2009
• Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Immediate-Early Proteins'

Definition: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.

Registry Number: 0

Descriptor UI: D017874

Alternative terms: Immediate-Early Proteins; Immediate Early Proteins; Proteins, Immediate-Early; Proteins, Immediate Early;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.460; D12.776.964.925.968;

History Note: 94

Technical Notes: proteins coded by immed-early genes: read MeSH definition for history of "immediate-early"