Immune Tolerance - Research News and Information

Saturday, January 10, 2009

Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases.

30 Oct 2008 A host can evolve two types of defence mechanism to increase its fitness when challenged with a pathogen: resistance and tolerance. Immunology is a well-defined field in which the mechanisms behind resistance to infection are dissected. By ... Read more...

New developments in mast cell biology.

30 Oct 2008 Mast cells can function as effector and immunoregulatory cells in immunoglobulin E-associated allergic disorders, as well as in certain innate and adaptive immune responses. This review focuses on exciting new developments in the field of mast cell ... Read more...

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.

30 Oct 2008 Advances in the understanding of the cells of the hematopoietic system have provided a rich basis for improving clinical hematopoietic cell transplants; finding and using proteins and molecules to amplify or suppress particular blood cell types; ... Read more...

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Latest indexed articles for 'Immune Tolerance'

These are the very latest articles for this heading:

• Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. 30 Oct 2008
• New developments in mast cell biology. 30 Oct 2008
• Consider delayed immunosuppression into the concept of sepsis. 30 Oct 2008
• The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases. 30 Oct 2008
• Identification of an expressed truncated form of CD200, CD200tr, which is a physiologic antagonist of CD200-induced suppression. 25 Oct 2008
• Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts. 25 Oct 2008
• Operational tolerance in nonvascularized transplant models induced by AR-C117977, a monocarboxylate transporter inhibitor. 25 Oct 2008
• Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells. 13 Oct 2008
• XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. 13 Oct 2008
• alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. 11 Oct 2008
• Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. 11 Oct 2008
• Immunology. Regulating suppression. 8 Oct 2008
• CTLA-4 control over Foxp3+ regulatory T cell function. 8 Oct 2008
• How tumours escape mass destruction. 7 Oct 2008
• Hepatitis B virus infection. 30 Sep 2008
• Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells. 30 Sep 2008
• Genetic divergence of hepatitis C virus: the role of HIV-related immunosuppression. 29 Sep 2008
• [Molecular mechanisms and diagnosis of autoimmune hemolytic anemia] 29 Sep 2008
• Complement production and regulation by dendritic cells: molecular switches between tolerance and immunity. 29 Sep 2008
• Tolerance to self: which cells kill? 28 Sep 2008

See a longer list of these articles.

Technical information about 'Immune Tolerance'

Definition: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

Descriptor UI: D007108

Alternative terms: Immune Tolerance; Tolerance, Immune; Immunosuppression (Physiology); Immunosuppressions (Physiology);

Related Mesh Headings: Graft vs Host Disease; Immunosuppression; Immunocompromised Host;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G12.425.484;

History Note: 66(64)

Technical Notes: do not confuse X ref IMMUNOSUPPRESSION (PHYSIOLOGY) with the Cat E immunol technique IMMUNOSUPPRESSION: Manual 28.21.1